Study of the transdentinal diffusion of bioactive molecules

Passos, A.D.; Tziafas, Dimitris; Mouza, A.A.; Paras, S.V.

doi:10.1016/j.medengphy.2016.09.005

Cited by 2 publications

(9 citation statements)

References 23 publications

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“…Several studies confirmed the suitability of CFD for dental pulp study e.g., [13][14][15][16]. In a previous study [17], we have numerically investigated the delivery of bioactive therapeutic agents to the dentin-enamel junction (DEJ) through a typical dentin tubule that has no obstructions or alterations of any type. The results of this initial approach led to the formulation of a simplified model that is able to estimate the initial drug concentration that must be imposed, so as a given type of therapeutic molecules to be effectively transported through a single and enclosed dentinal tubule.…”

Section: Introductionmentioning

confidence: 79%

“…Figure 1. (a) dentinal tubules running perpendicularly from pulpal wall towards dentino-enamel junction (DEJ) scanning electron microscopy (SEM), reproduced with permission from [17] and (b) dentinal disc of a human tooth.…”

Section: Transport Of Therapeutic Compounds Through the Dentinal Tissuementioning

confidence: 99%

“…After the silicone was set, all of the joints were reinforced externally with sticky wax (Kem-den, Purton, UK) and the whole system was filled with Ringer's solution (Vioser, Iraklio, Greece) to be checked for leakages. The experimental conduit, which is schematically presented in (a) dentinal tubules running perpendicularly from pulpal wall towards dentino-enamel junction (DEJ) scanning electron microscopy (SEM), reproduced with permission from [17] and (b) dentinal disc of a human tooth.…”

Section: Code Validationmentioning

confidence: 99%

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Computational Modelling for Efficient Transdentinal Drug Delivery

Passos

Tziafas

Mouza

et al. 2017

Fluids

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This work deals with the numerical investigation of the delivery of potential therapeutic agents through dentinal discs (i.e., a cylindrical segment of the dentinal tissue) towards the dentin-pulp junction. The aim is to assess the main key features (i.e., molecular size, initial concentration, consumption rate, disc porosity and thickness) that affect the delivery of therapeutic substances to the dental pulp and consequently to define the necessary quantitative and qualitative issues related to a specific agent before its potential application in clinical practice. The computational fluid dynamics (CFD) code used for the numerical study is validated with relevant experimental data obtained using micro Laser Induced Fluorescence (µ-LIF) a non-intrusive optical measuring technique. As the phenomenon is diffusion dominated and strongly dependent on the molecular size, the time needed for the concentration of released molecules to attain a required value can be controlled by their initial concentration. Finally, a model is proposed which, given the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tissue along with the aforementioned key design parameters, is able to estimate the initial concentration to be imposed and vice versa.

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Section: Introductionmentioning

confidence: 79%

Section: Transport Of Therapeutic Compounds Through the Dentinal Tissuementioning

confidence: 99%

Section: Code Validationmentioning

confidence: 99%

See 1 more Smart Citation

Computational Modelling for Efficient Transdentinal Drug Delivery

Passos

Tziafas

Mouza

et al. 2017

Fluids

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“…In an effort to obtain a generalized correlation concerning the delivery of agents through porous domains to the dental pulp that could simulate human dentin tissues, we employed and modified a previous proposed correlation [15] concerning the diffusion through a typical dentinal tubule (Eq. 6): Eq.…”

Section: Prediction Of the Drug Pulpal Concentrationmentioning

confidence: 99%

“…[12][13][14]. The simple case that concerns delivery of bioactive therapeutic agents to the dentin-enamel junction (DEJ) through a typical dentin tubule that has no obstructions or alterations of any type has been numerically studied in our Laboratory [15]. The results of this initial approach led to the formulation of a simplified model that is able to estimate the initial drug concentration to be imposed when a given type of therapeutic molecules are transported through a single and enclosed dentinal tubule.…”

Section: Introductionmentioning

confidence: 99%

Computational Modelling for Efficient Transdentinal Drug Delivery

Passos¹,

Tziafas²,

Mouza³

et al. 2017

Preprint

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This work deals with the numerical investigation of the delivery of potential therapeutic agents through dentinal discs (i.e. a cylindrical segment of the dentinal tissue) towards the dentin-pulp junction. The aim is to assess the main key features (i.e. molecular size, initial concentration, consumption rate, disc porosity and thickness) that affect the delivery of therapeutic substances to the dental pulp and consequently to define the necessary quantitative and qualitative issues related to a specific agent before its potential application in clinical practice. The CFD code used for the computational study is validated with relevant experimental data obtained using micro Laser Induced Fluorescence (μ-LIF) a non-intrusive optical measuring technique. As the phenomenon is diffusion dominated and strongly dependent on the molecular size, the time needed for the concentration of released molecules to attain a required value can be controlled by their initial concentration. Finally, a model is proposed which, given the maximum acceptable time for the drug concentration to attain a required value at the pulpal side of the tissue along with the aforementioned key design parameters, is able to estimate the initial concentration to be imposed and vice versa.

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Study of the transdentinal diffusion of bioactive molecules

Cited by 2 publications

References 23 publications

Computational Modelling for Efficient Transdentinal Drug Delivery

Computational Modelling for Efficient Transdentinal Drug Delivery

Computational Modelling for Efficient Transdentinal Drug Delivery

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