Thermal barrier coatings can be used to reduce the heat losses in heavy-duty diesel engines. A relatively new coating method for thermal barrier coatings is suspension plasma-spraying. Single-cylinder engine tests have been run to evaluate how heat losses to piston, cylinder head and exhausts as well as the specific fuel consumption are influenced by coating pistons with two different suspension plasma-sprayed thermal barrier coatings and one atmospheric plasma-sprayed thermal barrier coating, and comparing the results to those from an uncoated steel piston. The two suspension plasma-sprayed thermal barrier coatings showed reduced heat losses through the piston and less heat redirected to the cylinder head compared to conventional atmospheric plasma-sprayed thermal barrier coating, while one suspension plasma-sprayed coating with yttria-stabilized zirconia as top coat material showed increased exhaust temperature. However, the indicated specific fuel consumption was higher for all tested thermal barrier coatings than for an uncoated engine. The best performing thermal barrier coating with respect to indicated specific fuel consumption was a suspension plasma-sprayed coating with gadolinium zirconate as top coat material.