Study of the vitamins A, E and C esters penetration into the skin by confocal Raman spectroscopy in vivo

Mogilevych, Borys; Isensee, Debora; Rangel, João Lucas; Pizzol, Carine Dal; Martinello, Valeska Cristina Azevedo; Dieamant, Gustavo; Martin, Aírton Abrahão

doi:10.1117/12.2181016

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…The peaks observed in the Raman spectrum indicate the presence of UHMWPE, which corresponds to the peak values of 1078, 1132 and 2889 (Zavgorodnev et al , 2015). The peaks obtained at 1295, 1492 and 2940 correspond to the presence of vitamin C (Mogilevych et al , 2015) and the peak values of 1,379, 1,577 and 2,750 verify the existence of GNPs added as filler (Ferrari, 2007; Matis et al , 2012).…”

Section: Methodsmentioning

confidence: 99%

Fabrication and tribological behavior of novel UHMWPE/vitamin-C/graphene nanoplatelets based hybrid composite for joint replacement

Hussain

Saleem

Ahmad

2021

ILT

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Purpose This study aims to fabricate and investigate the tribological performance of ultra-high molecular weight polyethylene (UHMWPE)-based composite materials reinforced with 0.5, 1 and 2 weight percentage of graphene nanoplatelets (GNPs) while keeping the weight percentage of vitamin C constant at 2% for each composite. Design/methodology/approach In this paper, the composites were fabricated using hot pressing, and the dispersion of GNP/vitamin C/UHMWPE hybrid composite was investigated by X-ray diffraction. Experimental trials were performed according to ASTM F732 on a reciprocating sliding tribometer (pin-on-disc) at human body temperature of 37 ± 1 °C, for a load of 52 N, to assess the role of these fillers on the tribological properties of UHMWPE against Ti6Al4V counter body material under dry and lubricating (human serum) environment. Findings In this study, it has been observed that friction and wear behavior of the developed composites improve with increase in weight percentage of GNP, and human serum adheres to the surface of the composite pins upon sliding, resulting in the formation of a film, which results in better wear resistance of the composite pins under human serum lubrication than dry sliding. Scanning electron microscope was used to investigate the worn surface morphological examination of the composite materials. Specific wear rate of 0.76 × 10−7 mm3/Nm was attained for 2 Wt.% GNP-filled composite under human serum lubrication. Practical implications The results indicate the compatibility of the composite material used in this study and suggested the in vitro implant application. Originality/value The presented work includes novel study of synergistic effect of GNP (which acts as a solid lubricant) and vitamin C (added as an antioxidant) on the tribological performance of UHMWPE under dry and human serum lubrication.

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Section: Methodsmentioning

confidence: 99%

Fabrication and tribological behavior of novel UHMWPE/vitamin-C/graphene nanoplatelets based hybrid composite for joint replacement

Hussain

Saleem

Ahmad

2021

ILT

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“…In vivo confocal Raman spectroscopy is a powerful non-invasive technique that allows an analysis of skin constituents [24][25][26][27][28][29] related to biochemical composition, permeation processes [27][28][29][30] of the skin and RA, and it can replace other methods such as skin biopsy and tape tripping [31,32].…”

Section: Introductionmentioning

confidence: 99%

In vivo confocal Raman spectroscopy and molecular dynamics analysis of penetration of retinyl acetate into stratum corneum

Santos

Sousa

et al. 2017

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Study of the vitamins A, E and C esters penetration into the skin by confocal Raman spectroscopy in vivo

Cited by 2 publications

References 2 publications

Fabrication and tribological behavior of novel UHMWPE/vitamin-C/graphene nanoplatelets based hybrid composite for joint replacement

Fabrication and tribological behavior of novel UHMWPE/vitamin-C/graphene nanoplatelets based hybrid composite for joint replacement

In vivo confocal Raman spectroscopy and molecular dynamics analysis of penetration of retinyl acetate into stratum corneum

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