Study of Therapeutic Efficiency of New Blood Substitutes in Experimental Hemorrhagic Shock

Abstract

In experiments on dogs, which were anesthetized and underwent hemorragic shock, the hemodynamics, oxygen transport and acid-base status were studied. Cardiac function was studied using ultrasound equipment. It was established that administration of Volekam and Polyoxidin corrects hypovolemia with subsequent restoration of arterial pressure in the aorta and cardiac cavities and increase in the myocard contractility and cardiac output. Comparative analysis has shown that Polyoxidin exerts a more prolonged action than Volekam. In addition, Polyoxidin decreases the blood and plasma viscosity, lowers the blood cells aggregation which promotes the restoration of peripheral circulation. The efficiency of Volekam and Polyoxidin is not inferior to that of the well known blood substitute Polyglukin (dextran group) and, in respect of some parameters, is even superior to that of the latter.

PEG‐Hemoglobin as a Resuscitation Solution in the Treatment of Hypovolemic Shock in the Anesthetized Rat

“…Although the management of shock is generally guided by hemodynamic considerations, reports suggest that the true aim of therapy should be the optimization of oxygen delivery (1). Consequently, a number of oxygen‐carrying products have been developed and tested for their ability to either augment or replace these first response resuscitative solutions in both preclinical (2–10) and clinical hypovolemic settings (11,12). This work has shown that a complete resuscitation fluid should possess colloidal properties necessary to maintain blood pressure while delivering oxygen to vital peripheral ischemic tissues.…”