Study of thyroid function among COVID-19-affected and non-affected people during pre and post-vaccination

Razu, Mamudul Hasan; Hossain, Md. Iqbal; Ahmed, Zabed Bin; Bhowmik, Mousumi; Hasan, Md Kazy Ebnul; Kibria, Md. Kaderi; Moni, Dil Afroj; Khan, M. Nuruzzaman

doi:10.1186/s12902-022-01187-0

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…The former occurs due to the impaired hypothalamus-pituitary axis, while the latter results from a disruption in the thyroid gland. Hypothyroidism may also occur as a stage of thyroiditis [ 25 ]. In a study by Burokovic et al, the number of patients referring to the endocrinology clinic increased significantly in 2022 and 2021 compared to 2019 [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

The prevalence of thyroid disorders in COVID-19 patients: a systematic review and meta-analysis

Ashrafi,

Hatami,

Bidhendi-Yarandi

et al. 2024

BMC Endocr Disord

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Objectives To conduct a systematic review and meta-analysis to evaluate the prevalence of thyroid disorders in COVID-19 patients. Data sources Scopus, PubMed, ISI Web of Science, and Google Scholar databases were used in this review. We also consider the results of grey literature. Study selections Cohort, cross-sectional, and case-control studies were included. Data extraction and synthesis The required data were extracted by the first author of the article and reviewed by the second author. The Pooled prevalence of outcomes of interest was applied using the meta-prop method with a pooled estimate after Freeman-Tukey Double Arcsine Transformation to stabilize the variances. Outcomes and measured The different thyroid disorders were the main outcomes of this study. The diseases include non-thyroidal illness syndrome, thyrotoxicosis, hypothyroidism, isolated elevated free T4, and isolated low free T4. Results Eight articles were included in our meta-analysis(Total participants: 1654). The pooled prevalence of events hypothyroidism, isolated elevated FT4, isolated low FT4, NTIS, and thyrotoxicosis were estimated (Pooled P = 3%, 95% CI:2–5%, I2: 78%), (Pooled P = 2%, 95% CI: 0–4%, I2: 66%), (Pooled P = 1%, 95% CI: 0–1%, I2: 0%), (Pooled P = 26%, 95% CI: 10–42%, I2: 98%), and (Pooled P = 10%, 95% CI: 4–16%, I2: 89%), respectively. Conclusion Thyroid dysfunction is common in COVID-19 patients, with a high prevalence of non-thyroidal illness syndrome (NTIS) and thyrotoxicosis. Our meta-analysis found a 26% prevalence of NTIS and a 10% prevalence of thyrotoxicosis. Systematic review registration PROSPERO CRD42022312601.

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Section: Discussionmentioning

confidence: 99%

The prevalence of thyroid disorders in COVID-19 patients: a systematic review and meta-analysis

Ashrafi,

Hatami,

Bidhendi-Yarandi

et al. 2024

BMC Endocr Disord

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“…TSH is produced in the brain to stimulate the thyroid gland in order to produce and release more thyroid hormone [39]. Viral diseases like Chronic HBV (Hepatitis B viruses) infections and Covid viruses can be associated with changes in the level of these hormones [40,41].…”

Section: Discussionmentioning

confidence: 99%

IFN-γ, IL-17, IL-22+ CD4+ subset in patients with hepatitis C virus and correlation with clinical factor

Khansalar

2024

Am J Clin Exp Immunol

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Background: CD4 + T cell responses in HCV infection have a crucial role in the immunopathology of hepatitis C virus (HCV) infection. Our aim was to investigate the frequency of Th1, Th17, and Th22 cells in HCV-infected patients and elucidate their role in the progression of the disease. Methods: Twenty-six HCV-infected patients and 26 healthy individuals were recruited. Peripheral blood mononuclear cells (PBMCs) were stained to separate CD4, IFN-γ, IL-17, and IL-22 producing cells using flow cytometry. Results: Results showed that the mean expression of IL-22 in CD4 + T cells was significantly lower in HCV-infected patients compared to healthy controls. About correlation with clinical factor and T subsets, a negative correlation between the frequency of CD4 + IFN-γ + cells and Thyroxine level (T4) was observed in the patients. The data showed a positive link between thyroid-stimulating hormone (TSH), cholesterol levels, and the frequency of Th17 cells. In addition, a positive correlation was seen between serum creatinine level with both Th1 and Th17. Ultimately, it was found that there was a positive link between viral burden and IL-17 + IL-22 + cells and a negative correlation between viral load and pure Th22. Conclusions: Our findings indicate that Th22 cells may play a part in the immunopathology of HCV and show the associations between Thelper subsets and the clinical signs of the disease.

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“…Осложнения, связанные с щитовидной железой, обсуждаются в обзоре M. H. Razu с соавт. [161]. Поскольку патогенез тиреотоксикоза связан с Т-хелперами 1-го типа и стимулирующим действием IFN-γ, а иммунный ответ на вакцину BNT162b2 был именно такого типа, то влияние вакцины, возможно, реализуется через изменение популяции Т-клеток в пользу Th1 с образованием антител, стимулирующих рецептор к тиреотропному гормону гипофиза [162].…”

Section: эндокринологические осложненияunclassified

SARS-CoV-2 post-vaccination adverse reports: A review

Proskurnina,

Ivanov,

Redko

2023

Vestnik SPbSU. Medicine

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Acute respiratory infection caused by the SARS-CoV-2 coronavirus was the cause of the pandemic announced in March 2020. To prevent this disease, various vaccines have been developed and introduced into mass use, including on an innovative gene platform. The aim of the review is to analyze foreign literature on post-vaccination complications with the use of foreign vaccines, as well as whole-virion vaccines for the period 2021 — January 2023. The sources used in the publication were obtained from the Medline database, as well as articles in peer-reviewed journals and official reports. Post-vaccination complications are associated with specific damage to organs or systems either directly by the vaccine itself or indirectly as a result of exacerbation of the chronic process. The pathogenesis of post-vaccination complications depends on the composition of the vaccine. All complications were grouped by organs and systems. Vaccines containing SARS-CoV-2 antigens can activate autoimmune reactions due to homology, as well as activation of existing reactions in predisposed patients, which is confirmed by the effectiveness of immunosuppressive therapy. Innovative platforms using gene technologies are so complex and profoundly active that they can be introduced into broad medical practice only after a thorough and comprehensive study of the effects and mechanisms. Scientific achievements should follow the ethical principles of healing, and above all primum non nocere. Experts around the world emphasize the need for continued monitoring of people’s condition in order to protect their health and assess the long-term safety of drugs.

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Study of thyroid function among COVID-19-affected and non-affected people during pre and post-vaccination

Cited by 6 publications

References 24 publications

The prevalence of thyroid disorders in COVID-19 patients: a systematic review and meta-analysis

The prevalence of thyroid disorders in COVID-19 patients: a systematic review and meta-analysis

IFN-γ, IL-17, IL-22+ CD4+ subset in patients with hepatitis C virus and correlation with clinical factor

SARS-CoV-2 post-vaccination adverse reports: A review

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