Study of Thyroid Profile in Geriatric Type-2 Diabetics in Jharkhand

Abstract

Objective: To study the association of the two endocrinal disorders (diabetes mellitus and thyroid disease) in randomly selected geriatric patients. Methods:The study includes 80 patients in geriatric age groups with Type-2 diabetes mellitus visiting the medicine outpatients department. Thyroid profile was assayed in Type-2 diabetic patients.Results: It was noted that thyroid dysfunction was prevalent in 41 (51.25%) out of the 80 geriatric age group patients with 31 (38.75%) being hypothyroidism, 7 (8.7%) having subclinical hypothyroidism, and 3 (3.7%) having a hyperthyroid state. Conclusion:The study shows that screening should be strongly recommended for all Type-2 diabetics to rule out thyroid dysfunction in patients with increasing age.

Altered Lipid Profile in Hypothyroidism: A Biochemical Viewpoint

“…THs increase the synthesis and mobilization of TGs stored in the adipose tissue, which is reflected as an increase in the concentration of non-esterified fatty acids [31]. THs stimulate the lipoprotein lipase (LPL), which catabolizes the TG-rich LPs, and the HL, which hydrolyzes HDL 2 to HDL 3 and contributes to the conversion of IDL to LDL and in turn LDL to sdLDL [4,29,32]. HL also serves as a ligand that facilitates the uptake of LP by cell-surface receptors and proteoglycans, thus directly affecting cellular lipid delivery [32].…”

“…THs stimulate the lipoprotein lipase (LPL), which catabolizes the TG-rich LPs, and the HL, which hydrolyzes HDL 2 to HDL 3 and contributes to the conversion of IDL to LDL and in turn LDL to sdLDL [4,29,32]. HL also serves as a ligand that facilitates the uptake of LP by cell-surface receptors and proteoglycans, thus directly affecting cellular lipid delivery [32]. Furthermore, T 3 upregulates LDL receptors by controlling the LDL receptor gene activation.…”