Study of Tinnitus Induced Temporarily by Noise

Atherley, G. R. C.; Hempstock, T.I.; Noble, William

doi:10.1121/1.1911288

Cited by 67 publications

(63 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chronic tinnitus was induced by unilateral acoustic trauma, i.e., a single exposure to a 4 kHz tone at 80 dB (SPL), which produced a moderate temporary ipsilateral threshold elevation. Acoustic trauma in humans is commonly associated with tonal tinnitus (Loeb and Smith, 1967;Atherley et al, 1968). In the present study, chinchillas exposed to acoustic trauma showed a significant bilateral elevation of putative DCN fusiform cell spontaneous activity.…”

Section: Dcn Activity and Tinnitussupporting

confidence: 52%

“…When acute tinnitus is experimentally induced in human subjects using acoustic trauma, the resulting tinnitus is typically tonal, although its pitch has been reported to be quite variable. When the trauma stimulus was a pure tone, tinnitus frequency tended to be higher than the trauma frequency (Loeb and Smith, 1967), whereas 1/3-octave band noise produced tinnitus that was of lower frequency than the trauma stimulus (Atherley et al, 1968). In the present study, the maximum temporary unilateral threshold elevation, caused by ipsilateral trauma at 4 kHz, appeared between 6 and 8 kHz (Fig.…”

Section: Tinnitus Versus Hearing Losssupporting

confidence: 46%

See 1 more Smart Citation

Elevated Fusiform Cell Activity in the Dorsal Cochlear Nucleus of Chinchillas with Psychophysical Evidence of Tinnitus

Brozoski¹,

Bauer²,

2002

View full text Add to dashboard Cite

Chinchillas with psychophysical evidence of chronic tinnitus were shown to have significantly elevated spontaneous activity and stimulus-evoked responses in putative fusiform cells of the dorsal cochlear nuclei (DCN). Chinchillas were psychophysically trained and tested before and after exposure to a traumatic unilateral 80 dB (sound pressure level) 4 kHz tone. Before exposure, two groups were matched in terms of auditory discrimination performance (noise, and 1, 4, 6, and 10 kHz tones). After exposure, a single psychophysical difference emerged between groups. The exposed group displayed enhanced discrimination of 1 kHz tones ( p ϭ 0.00027). Postexposure discrimination of other stimuli was unaffected. It was hypothesized that exposed animals experienced a chronic subjective tone (i.e., tinnitus), resulting from their trauma, and that features of this subjective tone were similar enough to 1 kHz to affect discrimination of 1 kHz objective signals. After psychophysical testing, single-unit recordings were obtained from each animal's DCN fusiform cell layer. Putative fusiform cells of exposed animals showed significantly ( p ϭ 0.0136) elevated spontaneous activity, compared with cells of unexposed animals. Putative fusiform cells of exposed animals showed a greater stimulus-evoked response to tones at 1 kHz ( p ϭ 0.0000006) and at characteristic-frequency ( p ϭ 0.0000009). This increased activity was more pronounced on the exposed side. No increase in stimulus-evoked responses was observed to other frequencies or noise. These parallel psychophysical and electrophysiological results are consistent with the hypothesis that chronic tonal tinnitus is associated with, and may result from, trauma-induced elevation of activity of DCN fusiform cells.

show abstract

Section: Dcn Activity and Tinnitussupporting

confidence: 52%

Section: Tinnitus Versus Hearing Losssupporting

confidence: 46%

Elevated Fusiform Cell Activity in the Dorsal Cochlear Nucleus of Chinchillas with Psychophysical Evidence of Tinnitus

Brozoski¹,

Bauer²,

2002

View full text Add to dashboard Cite

show abstract

“…The horizontal dashed line indicates the .01, one-tailed criterion level as that induced by salicylate or other chemicals. However, since it is well established that tinnitus caused by exposing one ear to a loud sound is always lateralized to the exposed ear (Atherley et al, 1968;Davis et al, 1950;Loeb & Smith, 1967), this procedure should work well for tinnitus caused by overstimulating or otherwise damaging one ear.…”

Section: Discussionmentioning

confidence: 99%

“…The three available studies of sound-induced tinnitus in humans suggest that we may make this assumption (Atherley, Hempstock, & Noble, 1968;Davis et al, 1950;Loeb & Smith, 1967). Specifically, each of these studies determined the preexposure absolute thresholds of the subjects, exposed one ear to loud sounds, determined the postexposure absolute thresholds in the exposed ear, and had the subjects match the resulting tinnitus to tones presented to the unexposed ear.…”

mentioning

confidence: 99%

A two-choice sound localization procedure for detecting lateralized tinnitus in animals

Heffner

2011

Behav Res

View full text Add to dashboard Cite

Rats were trained in a two-choice procedure to respond in the direction of left and right sounds. Silent trials, on which no sound was presented and for which the animals received no feedback, were interspersed among the sound trials to determine each animal's natural side preference. Following training, the rats were exposed to a loud tone in the ear opposite their side preference. A shift in responding on the silent trials to the side of the exposed ear indicated that the animals were hearing a sound in that ear (i.e., tinnitus). Simulating lateralized tinnitus by presenting a low-level, continuous sound on one side also caused the rats to shift their responding on the silent trials to that side. Sham exposures indicated that halothane/nitrous oxide anesthesia could reinstate tinnitus in animals that had previously tested positive for it. Exposing rats to loud tones of various frequencies indicated that frequencies near the limits of the rat's hearing range were less likely to cause tinnitus than tones in the midrange.

show abstract

“…Central tinnitus models, on the other hand, are able to account for these tinnitus subtypes. Conversely, central tinnitus models hardly account for acute tinnitus induced immediately after noise trauma [Loeb and Smith, 1967;Atherley et al, 1968] as the noise-induced hyperactivity in the auditory centres takes a few minutes to hours to develop Mulders and Robertson, 2013]. It has been proposed, however, that acute noise-induced tinnitus could be related to the cortical hypersynchrony resulting from the rapid unmasking of thalamocortical connections after noise trauma .…”

Section: Resultsmentioning

confidence: 99%

Revisiting the Cochlear and Central Mechanisms of Tinnitus and Therapeutic Approaches

Noreña¹

2015

Audiol Neurotol

104

View full text Add to dashboard Cite

This short review aims at revisiting some of the putative mechanisms of tinnitus. Cochlear-type tinnitus is suggested to result from aberrant activity generated before or at the cochlear nerve level. It is proposed that outer hair cells, through their role in regulating the endocochlear potential, can contribute to the enhancement of cochlear spontaneous activity. This hypothesis is attractive as it provides a possible explanation for cochlear tinnitus of different aetiologies, such as tinnitus produced by acute noise trauma, intense low-frequency sounds, middle-ear dysfunction or temporomandibular joint disorders. Other mechanisms, namely an excitatory drift in the operating point of the inner hair cells and activation of NMDA receptors, are also briefly reported. Central-type tinnitus is supposed to result from aberrant activity generated in auditory centres, i.e. in these patients, the tinnitus-related activity does not pre-exist in the cochlear nerve. A reduction in cochlear activity due to hearing loss is suggested to produce tinnitus-related plastic changes, namely cortical reorganisation, thalamic neuron hyperpolarisation, facilitation of non-auditory inputs and/or increase in central gain. These central changes can be associated with abnormal patterns of spontaneous activity in the auditory pathway, i.e. hyperactivity, hypersynchrony and/or oscillating activity. Therapeutic approaches aimed at reducing cochlear activity and/or tinnitus-related central changes are discussed.

show abstract

Study of Tinnitus Induced Temporarily by Noise

Cited by 67 publications

References 0 publications

Elevated Fusiform Cell Activity in the Dorsal Cochlear Nucleus of Chinchillas with Psychophysical Evidence of Tinnitus

Elevated Fusiform Cell Activity in the Dorsal Cochlear Nucleus of Chinchillas with Psychophysical Evidence of Tinnitus

A two-choice sound localization procedure for detecting lateralized tinnitus in animals

Revisiting the Cochlear and Central Mechanisms of Tinnitus and Therapeutic Approaches

Contact Info

Product

Resources

About