Study of total antioxidant capacity of red raspberry (Rubus idaeous L.) shoots

Maslov, O. Yu.; Komisarenko, M. A.; Golik, N. Yu.; Kolisnyk, S. V.; Altukhov, A. A.; Baiurka, S. V.; Karpushina, S. A.; Ткаченко, Оксана Борисовна; Iuliia, Kolisnyk

doi:10.17533/udea.vitae.v30n1a351486

Cited by 7 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our studies, it was found that green tea leaf is rich in catechins (epigallocatechin3Ogallate, epicatechin, (+)catechin), flavonols (rutin, quercetin), organic (citric, oxalic acid) and phenylcarboxylic acids (gallic, quinic and caffeic acid) [6,7]. The main group of compounds in green tea leaf are catechins that have antioxidant, anti-inflammatory, antimicrobial, and antifungal effects [8,9].…”

Section: Original Researchmentioning

confidence: 90%

Antioxidant, antimicrobial and antifungal activity of the obtained “Cachisept” tablets for resorption in the oral cavity for the treatment and prevention of dental caries

Maslov,

Komisarenko,

Ponomarenko

et al. 2023

CIPM

View full text Add to dashboard Cite

Dental caries stands as a highly common chronic ailment affecting individuals globally, with susceptibility to this condition spanning their entire lifespan. Consequently, the search for novel medications aimed at treating and preventing dental caries holds significant importance in the field of pharmacy. The aim of the work was to study the antioxidant, antimicrobial, and antifungal activity of the obtained oral tablets “Сaсhisept” for resorption in the oral cavity for the treatment and prevention of dental caries. Materials and methods. The obtained tablets “Сaсhisept” with green tea leaf extract were the object of investigation. Antioxidant activity was established by the potentiometric method, and antimicrobial and antifungal activity was assessed by the agar well diffusion method. Results. The level of antioxidant activity for tablets “Сaсhisept” was 110.00 ± 2.20 mmol-eqv./mdry res, the obtained tablets had a high level of antioxidant activity according to Maslov’s conditional classification. Staphylococcus aureus (25.33 ± 0.50 mm), Baсillus subtilis (25.33 ± 0.50 mm) and Streptococcus mutans (25.33 ± 0.50 mm) were the most sensitive to the obtained “Сaсhisept” tablets, and the least – Proteus vulgaris (20.67 ± 0.50 mm), and it was observed strong growth inhibition in relation to the fungus Candida albicans (20.00 ± 0.50 mm). Conclusions. The presented study has found that “Сaсhisept” tablets have a high level of antioxidant activity, and also have a high antimicrobial and antifungal effect against all investigated Gram-positive, Gram-negative bacteria, and the Candida albicans fungus. Thus, “Сaсhisept” tablets can be recommended for the treatment and prevention of dental caries.

show abstract

Section: Original Researchmentioning

confidence: 90%

Antioxidant, antimicrobial and antifungal activity of the obtained “Cachisept” tablets for resorption in the oral cavity for the treatment and prevention of dental caries

Maslov,

Komisarenko,

Ponomarenko

et al. 2023

CIPM

View full text Add to dashboard Cite

show abstract

“…In many chronic diseases such as diabetes mellitus, hypertension, atherosclerosis, Alzheimer's disease, and cancer [1], inflammation and oxidative stress invariably play pivotal roles. During the inflammatory response, neutrophils and macrophages generate substantial quantities of free radicals to combat and eliminate foreign invaders [2,3]. Furthermore, recent research has revealed that non-phagocytic cells, like interleukin-6 (IL-6), can also produce free radicals by expressing NADPH oxidase [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Inflammatory, Antioxidant Activities and Molecular Docking Analysis of Rubus idaeus Leaf Extract

Maslov,

Komisarenko,

Kolisnyk

et al. 2024

Jordan j. pharm. sci.

View full text Add to dashboard Cite

The study aimed to identify the most abundant compounds in raspberry leaf extract via HPLC analysis, conduct theoretical and practical assessments of antioxidant and anti-inflammatory activities both in silico, in vitro, and in vivo, and evaluate the correlation between antioxidant and anti-inflammatory activities. Polyphenols were quantified using HPLC; molecular docking was carried out using AutoDockTools 1.5.6; antioxidant activity was ascertained via the potentiometric method; and anti-inflammatory activity was examined based on the carrageenan edema method. The extract was found to be rich in epicatechin (0.417%), (+)-catechin (0.501%), and ellagitannins (0.401%). The free energy of (+)-catechin and epicatechin was -8.40 and -7.20 respectively for the active sites of cyclooxygenase-2 (COX-2), and -6.60 and -7.11 for nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase). Notably, the antioxidant activity of the raspberry leaf extract was 1.43%, 1.04%, and 10.62% higher than that of green tea leaf extract for doses of 4.00, 2.00, 0.20 mg/mL, respectively. Treatment with the raspberry leaf extract at a dose of 13.0 mg/kg resulted in a significant decrease in edema after 1, 2, and 3 hours by 38.8%, 41.8%, and 48.8%, respectively, compared to the control group. The study demonstrated a correspondence between experimental and theoretical results in evaluating antioxidant and anti-inflammatory activities. Correlation analysis further substantiated that the anti-inflammatory action is dependent on antioxidant activity.

show abstract

“…The human body has its own antioxidant system, which consists of the following enzymes: superoxide dismutase, catalase, and glutathione peroxidase [5,6]. However, due to endogenous or exogenous influences, the antioxidant system is not always able to completely inactivate free radicals, thereby increasing the risk of developing the diseases above.…”

mentioning

confidence: 99%

Investigation of antioxidant interaction between ascorbic acid and rutin in medicine “Ascorutin”

Maslov,

Komisarenko,

Kolisnyk

et al. 2024

Current issues in pharmacy and medicine: science and practice

View full text Add to dashboard Cite

Phytomedicines are combined pharmaceuticals containing various groups of phenolic compounds. It is known that phenolic compounds are powerful antioxidants, but their level of antioxidant activity during interactions has not been previously studied. The aim of the work was to investigate interaction between ascorbic acid and rutin in medicine “Ascorutin”. Materials and methods. The objects of the study were one series of tablets “Ascorutin,” rutin, and ascorbic acid. The level of antioxidant activity was measured by the potentiometric method. Results. The level of antioxidant activity of model solutions of rutin was 265.51 ± 1.00 mmol-eq./L, ascorbic acid – 99.00 ± 1.00 mmol-eq./L, a combination of rutin and ascorbic acid – 255.60 ± 1.00 mmol-eq./L, and medicine “Ascorutin” – 256.52 ± 1.00 mmol-eq./L. An experimental value of the level of antioxidant activity of “Ascorutin”, the combination of rutin and ascorbic acid was 30 % less than theoretical values. Conclusions. The antioxidant interaction of ascorbic acid and rutin in “Ascorutin” medicine has been studied. It has been established that the combination of rutin and ascorbic acid has an antagonistic effect. The findings of this research will serve as a stimulus for exploring the interaction of bioactive substances and selecting their optimal combinations for the development of pharmaceuticals, special food products, food, and cosmetic products.

show abstract

Study of total antioxidant capacity of red raspberry (Rubus idaeous L.) shoots

Cited by 7 publications

References 27 publications

Antioxidant, antimicrobial and antifungal activity of the obtained “Cachisept” tablets for resorption in the oral cavity for the treatment and prevention of dental caries

Antioxidant, antimicrobial and antifungal activity of the obtained “Cachisept” tablets for resorption in the oral cavity for the treatment and prevention of dental caries

Evaluation of Anti-Inflammatory, Antioxidant Activities and Molecular Docking Analysis of Rubus idaeus Leaf Extract

Investigation of antioxidant interaction between ascorbic acid and rutin in medicine “Ascorutin”

Contact Info

Product

Resources

About