Study of Toxoplasma gondii Infection in Patients with Bipolar Disorder

Khademvata, Shahram; Khajeddin, Niloufar; Izadi, Sakineh; Saki, Jasem

doi:10.3923/jms.2013.215.220

Cited by 10 publications

(1 citation statement)

References 7 publications

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“…Through the built research equation, we identified 2,604 articles in several languages (English, French, Spanish, Portuguese, Chinese, and Russian). Among the articles meeting our inclusion criteria, there were 18 co-morbidity studies on mental disorders and neurotropic parasitic diseases [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] (Figure 1) with two of those being prevalence studies in individuals with neurotropic parasitic diseases who were screened for mental disorders, and sixteen analytical studies in individuals with mental disorders who were screened for neurotropic parasitic diseases (Table 2 and Table 3). These studies were conducted between 1997 and 2016.…”

Section: General Resultsmentioning

confidence: 99%

Associations of mental disorders and neurotropic parasitic diseases: a meta-analysis in developing and emerging countries.

Daré

Bruand

Gérard

et al. 2019

Preprint

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Background Although they are declining worlwide, neurotropic parasitic diseases are still common in developing and emerging countries. The aim of this study was to estimate the pooled prevalence and pooled association measures of comorbidities between mental disorders (anxiety, depression, bipolar disorder, and schizophrenia) and neurotropic parasitic diseases (malaria, cysticercosis, toxoplasmosis, human African trypanosomiasis, Chagas disease, and human toxocariasis) in developing and emerging countries.Methods As the first meta-analysis on this topic, this study was performed in accordance with PRISMA guidelines. The protocol was registered in PROSPERO (N°CRD42017056521). The Medline, Embase, Lilacs, and Institute of Epidemiology and Tropical Neurology databases were used to search for articles without any restriction in language or date. We evaluated the quality of studies independently by two investigators using the Downs and Black assessment grid and pooled estimates using the random-effects method from CMA (Comprehensive Meta Analysis) Version 3.0..Results In total, 18 studies studies published between 1997 and 2016 met our inclusion criteria. We found that the prevalence of anxiety and depression in people suffering from Chagas disease and/or neurocysticercosis was 44.9% (95% CI, 34.4 – 55.9). In 16 pooled studies that included 1,782 people with mental disorders and 1,776 controls, toxoplasmosis and/or toxocariasis were associated with increased risk of schizophrenia and/or bipolar disorders (odds ratio = 2.3; 95% CI, 1.7 – 3.2). Finally, toxocariasis and/or toxoplasmosis were associated with an increased risk of the onset of schizophrenia (odds ratio = 2.4; 95% CI, 1.7 – 3.4).Conclusion Our pooled estimates show that the associations between diseases studied are relatively high in developing and emerging countries. This meta-analysis supports the hypothesis that toxoplasmosis could be the cause of schizophrenia. These findings could prove useful to researchers who want to further explore and understand the associations studied.

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