Study of Trace Elements Selenium, Copper, Zinc and Manganese Level in Polycystic Ovary Syndrome (PCOS)

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women, trace elements play an important role in PCOS, selenium performs various biological functions such as defense against oxidative stress, immune function and thyroid function, polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women, trace Elements have important role in PCOS, selenium is involved in many biological functions, such as, protection against oxidative stress, immune function and thyroid function, Copper, zinc and manganese are essential micronutrients that have been integrated into various proteins and metalloenzymes and are active in the metabolic process of cells and in oxidative stress pathways that can lead to oxidative stress. One hundred and twenty-four of patients' women with poly cystic ovarian syndrome (PCOS) patients and 56 normal ovulatory women participated in the study. Seleniumand serum Copper, zinc and manganese were measured by using flame atomic absorption spectrometry (FAAS).

Evaluating the clinical significance of RBP4, PAI-1, and some trace elements in women with Polycystic Ovary Syndrome

“…Therefore, decreased Se level may induce an increased risk factor of cardiovascular disorder, gestational complications, miscarriages, neurodegenerative diseases and increased risk of cancer. Women with PCOS are susceptible to infertility, hirsutism, increased inflammatory factors and increased biomarkers of oxidative stress 22 . Tumor necrosis factor-a (TNF-a), nuclear factor-kappa b (NF-jb), and interleukin-1 (IL-1) are a few examples of inflammatory cytokines that are prevented from being produced and active by selenium, according to numerous research (IL-1 and IL-18).…”

“…Therefore, a stable balance between the copper-zinc components is responsible for the effectiveness of enzyme function (SOD). Because of enzyme failure, the imbalance in the copper-to-zinc ratio may raise the ratio of dangerous free radicals in the body, which could cause serious harm to cell membranes and walls 22 . In our study, the PCOS group's copper/zinc ratio was noticeably higher than that of the control group.…”

The Content of Minerals in the PCOS Group and the Correlation with the Parameters of Metabolism

“…In our study, decreased membrane fluidity of RBC was associated with higher levels of plasma insulin. It is believed that magnesium deficiency can cause oxidative stress [ 19 , 45 ]. Hypomagnesaemia reduces the sensitivity of peripheral tissues to insulin by diminished autophosphorylation of tyrosine kinase, a component of the insulin β subunit of which magnesium is a cofactor [ 50 ].…”

“…Hypomagnesaemia may also be associated with decreased β-cell proliferation, thus affecting insulin production [ 51 , 52 ]. The magnesium content of red blood cells is a very good indicator of short-term magnesium status, and a low level indicates nutritional deficiencies [ 19 ]. In the presented study, the magnesium content in erythrocytes ranged from 34.0–66.8 mg/L and was slightly higher in women with PCOS than in the control group (statistically insignificant), whereas Mhaibes et al [ 49 ] and Swetha et al [ 53 ] observed significantly lower concentrations of this element in the serum of PCOS patients compared with the control group.…”

“…Copper, zinc, and manganese are the basic micronutrients that, along with numerous proteins and metalloenzymes, are essential in the metabolic systems of cells and in the oxidative stress pathways. In the first enzymatic step, superoxide dismutase (SOD) and glutathione-dependent enzymes (GSH) are the key antioxidants, copper-zinc SOD (Cu, Zn-SOD or SOD1) is found in the cytosol, and manganese SOD (Mn-SOD or SOD2) is located in the mitochondria [ 16 , 17 , 18 , 19 ].…”