Study of Various Pyridazine and Phthalazine Drugs with Diverse Therapeutical and Agrochemical Activities

Synthesis of Imidazo[1,2‐b]pyridazine Scaffold Based Amide Derivatives as Potential Inhibitors for Bacterial Activity

“…In summary, we designed and synthesized a series of C-8substituted N-methylpiperazine and methoxyimidazo[1,2b]pyridazine-based amide derivatives and evaluated their in vitro antibacterial activity. Among these compounds, paranitro aryl amide derivative (compounds 10 and 16) in both the N-methylpiperazine (7)(8)(9)(10)(11) and methoxy series (12-21) demonstrated significant antibacterial activity, showing promising…”

“…Interestingly, in the C-8 methyl piperazine series, the para-substituted methoxy aryl amide (10) imidazopyridazine derivatives showed significant antibacterial activity against P. aeruginosa with an MIC of 6.25 μg/mL. The synthesized compounds (7)(8)(9)(10)(11) in the C-8 methyl piperazine series showed insignificant inhibitory activity against the tested strains.…”

“…Pyridazine scaffold has been identified as an important sixmembered heterocyclic moiety with a wide range of applications in the fields of agriculture [5][6][7] and pharmaceuticals. [8][9][10] Many drugs in this category containing the pyridazine ring core have exhibited potential antimicrobial and antifungal activities. [11][12][13] Pyridazomycin (Figure 1), the first isolated pyridazine derivative, serves as an effective antifungal antibiotic agent.…”

Novel Pyran-Linked Phthalazinone-Pyrazole Hybrids: Synthesis, Cytotoxicity Evaluation, Molecular Modeling, and Descriptor Studies

“…Phthalazine and its derivative phthalazinone are heterocyclic scaffolds that are extensively explored for potential application in the treatment of a wide range of medical conditions (Vila et al, 2015). Given its significance as a pharmacophore, phthalazine is a key moiety in various new chemical entities that exhibit antidiabetic, anticonvulsant, anti-inflammatory, antihypertensive, and analgesic activities (Young Taek et al, 2017;Sangshetti et al, 2019;Mohd and Mohammad, 2020). Particularly, a wide array of phthalazine-derived compounds have been reported as anticancer agents for various molecular targets (Sung Kim et al, 2004;Loh et al, 2005;Wang et al, 2014).…”

Copper-catalysed dehydrogenative self-coupling/cyclization of 5-aminopyrazoles: synthesis and photophysical study of pyridazines

“…On the other hand, pyridazines have a wide range of pharmaceutical and industrial applications. 8 Some pyridazine derivatives such as hydralizine, 9 minaprine, 10 cadralazine 11 and pyridazomycin 12 are established drug molecules available in the market (Fig. 1).…”