Study of Vitamin D Receptor Gene Polymorphisms in Egyptian Patients with Primary Osteoporosis

doi:10.21608/ejaps.2015.184786

Egyptian Journal of Pure and Applied Science

2015

DOI: 10.21608/ejaps.2015.184786

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Study of Vitamin D Receptor Gene Polymorphisms in Egyptian Patients with Primary Osteoporosis

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2024

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VDR Gene Polymorphisms (BsmI, FokI, TaqI, ApaI) in Total Hip Arthroplasty Outcome Patients

Rozmus,

Fiedorowicz,

Grzybowski

et al. 2024

IJMS

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A total hip arthroplasty (THA) can improve quality of life, but loosening of the hip prosthesis is a complex problem in which vitamin D may also play a role. The Vitamin D Receptor (VDR) is involved in the response of cells to the action of vitamin D, and its genetic variability raises the question of whether individual differences could influence the risk of prosthesis loosening. The aim of this study was to investigate the relationship between VDR single nucleotide polymorphisms (SNPs) (ApaI, BsmI, FokI and TaqI) and the serum VDR and 25(OH)D levels in three groups of patients: (1) arthroscopy patients after THA without loosening of the prosthesis (CA—Control Arthroplasty), (2) patients after THA with loosened hip prostheses (L—Loosening) and (3) the control group (C—Control). Our results suggest that the genotypes tt of TaqI, BB of BsmI, and FF of FokI may influence the VDR effect in patients with loosened protheses. Our results showed that the ACAC haplotype (AtBF) was over two times more frequent in the L group than in CA + C: OR =2.35 [95% CI 1.44–3.83; p = 0.001]. There was no significant correlation between the VDR and serum 25(OH)D levels, but there were differences between studied groups.

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VDR Gene Polymorphisms (BsmI, FokI, TaqI, ApaI) in Total Hip Arthroplasty Outcome Patients

Rozmus,

Fiedorowicz,

Grzybowski

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Study of Vitamin D Receptor Gene Polymorphisms in Egyptian Patients with Primary Osteoporosis

Cited by 1 publication

References 44 publications

VDR Gene Polymorphisms (BsmI, FokI, TaqI, ApaI) in Total Hip Arthroplasty Outcome Patients

VDR Gene Polymorphisms (BsmI, FokI, TaqI, ApaI) in Total Hip Arthroplasty Outcome Patients

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