Background: There are controversial studies on weight loss, cardiometabolic markers, and quality of life (QOL) in obese aged women participating in water sports. Objectives: This study aimed to determine the effects of the WATERinMOTION exercise program accompanied with no diet on the inactive obese aged women’s weight, cardiometabolic markers, and QOL. Methods: Sixty-four inactive obese aged women were recruited to participate in this cross-sectional study at the Ukrainian Sports Center, Kyiv, 2019. They were randomly assigned into two Case (n = 32, with the WATERinMOTION aquatics exercise program) and control (n = 32, held in a sitting position simultaneously) groups using the convenient sampling method. The two programs were run twice a week (55 minutes each time) and lasted for one month. Moreover, anthropometric indices (weight, height, waist circumference), cardiometabolic markers (blood lipid markers and glycaemia), QOL (SF-36 questionnaire), and dietary monitoring were assessed before and after the intervention. Results: The groups did not differ significantly regarding each of the analyzed variables prior to the intervention. Comparing pre-and post-intervention results revealed significant weight loss (-1.3, P = 0.004) and average BMI (-0.4, P = 0.002) in the case group. Moreover, a significant variation was revealed only in terms of weight after the intervention (P = 0.001). Regarding QOL, improvements in health status, vitality, and social aspects were significant in the case group after the intervention. Conclusions: The present study suggests that the WATERinMOTION program accompanied with no diet has a positive effect on weight loss, waist circumference, and metabolic profiles in obese aged women. However, the improvement in the QOL should not be neglected.