Study of wetting of the animal retinas by Water and organic liquids and its Implications for ophthalmology

Rubowitz, Alexander; Ayalon, Anfisa; Roy, Pritam Kumar; Shoval, Shraga; Legchenkova, Irina; Bormashenko, Edward

doi:10.1016/j.colsurfb.2020.111265

Cited by 8 publications

(8 citation statements)

References 38 publications

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“…One might be mechanical effects, such as the motion of the eye during saccades 12 , 19 and another factor might be the recently described mechanism of the break-up of silicone oil 11 , 13 , 20 , 21 that allows increased adherence to the ocular tissue, thus promoting the formation of emulsion droplets. Biological surfactants derived from ocular tissue and blood (eg, fibrinogen, fibrin, γ-globulin, very-low-density-lipoprotein, and alpha-1-glycoprotein), 22 the amphiphilic properties of the retinal tissue itself, 23 as well as the presence of lipophilic substances increasingly contaminating the silicone oil; these are all implicated in influencing the rate of emulsification.…”

Section: Discussionmentioning

confidence: 99%

“…25 , 26 In fact, the retina itself displays both hydrophilic and lipophilic properties as shown by Rubowitz et al in 2020. 23 Based on Antonoff's rule, which states that the surface tension at the interface between two saturated liquid layers in equilibrium is equal to the difference between the individual surface tensions of similar layers when exposed to air, and later modifications to this rule: lower surface tension values can translate to a lower interfacial tension between silicone oils and biological hydrophilic media in the eye with an increased risk of emulsification. In our study, we did not see significant changes of surface tension of silicone oil after long-term intraocular use.…”

Section: Discussionmentioning

confidence: 99%

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Physicochemical Properties of Explanted Silicone Oil After Use as an Intraocular Tamponade

Hammer

Schickhardt

Munro

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose We studied the effects of exposure to biological media within the eye, such as contamination with lipophilic and amphiphilic substances, on the physicochemical parameters of silicone oil used as an intraocular tamponade. Methods We removed silicone oil with visible emulsification from 15 patients and measured each sample for shear viscosity and surface tension. We induced in vitro emulsification with balanced salt solution. Using the zeta-potential, we evaluated the emulsion droplet's electrochemical stability. We repeated all experiments in a control group of unused oil. Electrochemical stability and viscosity were additionally measured in oils with high-molecular-weight components. Results We recovered silicone oils implanted between 30 and 506 days (mean, 196 days). Viscosity did not differ between explanted and control groups. Surface tension and zeta potential remained unchanged ( P = 0.61 and P = 0.84, respectively). All oils showed a significant correlation of viscosity with temperature ( P < 0.01 for all). Oils with added high-molecular-weight components showed a lower emulsion stability. Conclusions Prolonged contact to hydrophilic biological media does not alter high-viscosity silicone oil's physicochemical parameters. During typical durations of intraocular use, lipophilic and amphiphilic molecules had no deleterious effect. The addition of high-molecular-weight components might decrease the silicone oil's electrochemical emulsion stability, possibly easing the confluence of emulsion droplets. Translational Relevance Although the physicochemical parameters of silicone oils are not altered after clinically relevant durations within the eye, emulsion stability significantly differs between oil types.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Physicochemical Properties of Explanted Silicone Oil After Use as an Intraocular Tamponade

Hammer

Schickhardt

Munro

et al. 2022

Trans. Vis. Sci. Tech.

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“…Inadequate SO tamponade following vitreoretinal surgery is often observed, 6 characterized by the presence of an oil-liquid interface under fundoscopy (Supplementary Digital Content, Figure 1, http://links.lww.com/APJO/A104). One major reason is that with the absorption of residual subretinal/suprachoroidal fluid and the regression of chorioretinal edema, the vitreous cavity is becoming larger than that before surgery.…”

Section: Discussionmentioning

confidence: 99%

“…5 However, the appearance of inferior redetachment following SO tamponade remains surgically challenging. Although the vitreous cavity is filled with SO intraoperatively, an oil-liquid interface can often be observed, 6 indicating insufficient SO tamponade (Supplementary Digital Content, Figure 1, http://links.lww.com/APJO/A104). This is mainly due to absorption of chorioretinal edema and residual subretinal and subchoroidal fluid in postoperative days, which enlarges the vitreous cavity.…”

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confidence: 99%

Adequate Silicone Oil Tamponade by Utilizing the Space of Anterior Segment for Complicated Retinal Detachment: Technique, Efficacy, and Safety

Wang

Huang

Zheng

et al. 2021

Asia-Pacific Journal of Ophthalmology

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Purpose: To evaluate the efficacy and safety of adequate silicone oil (SO) tamponade procedure in patients with complicated retinal detachment. Methods: Thirty-one eyes in 31 patients were enrolled in this prospective case series. Adequate SO tamponade was performed by injecting the SO into the vitreous cavity and the entire anterior chamber, followed by posterior capsulotomy and inferior peripheral iridotomy. Preoperative and follow-up data including retinal anatomic reattachment and SO status, best-corrected visual acuity, intraocular pressure, surgical complications and management were collected and analyzed. Results: Twenty-nine eyes presented with complete retinal reattachment after subsequent SO removal with a primary success rate of 93.5%. Seventeen patients (54.8%) had complete anterior chamber SO migration to the vitreous cavity within the first postoperative day. The average time for anterior chamber SO migration was 2.3 ± 1.8 days. No oil-fluid interface in the vitreous cavity was observed in all the eyes, indicating a relatively adequate SO tamponade. Acute intraocular pressure elevation occurred in 16 (51.6%) eyes and was controllable under medication (n = 16) and anterior chamber paracentesis (n = 1). Two patients developed recurrent retinal detachment and received SO removal and a secondary adequate SO tamponade. At final follow-up, all the eyes had SO removal for at least 3 months and retinas maintained completely attached. Conclusions: The adequate SO tamponade procedure offers a simple, safe, and efficacious treatment alternative for complicated retinal detachment.

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“…Previous studies 2 that have investigated the static and dynamic contact of tamponades have provided important information gained through the use of phantom eyes and the computational fluid dynamics (CFD) of idealized eye models, but far less information has been obtained regarding the behavior of silicone oil (SiO) tamponade in eyes with geometric variations. Variants 3 of the eye morphology, such as the presence of a posterior staphyloma in pathologic myopia or iatrogenic modifications induced by an encircling scleral band, may significantly alter the vitreous chamber contour from theoretical models, challenging the validity of acquired results.…”

Section: Introductionmentioning

confidence: 99%

Silicone Oil Tamponade–Retina Contact in Highly Myopic Eyes With and Without Encircling Bands: A Computational Fluid Dynamics Study

Rossi

Querzoli

Badas

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose To investigate the behavior of silicone oil (SiO) at a steady equilibrium and during saccades in pseudophakic highly myopic eyes with posterior staphyloma with and without an encircling band and compare it to behavior in emmetropic eyes. The SiO–retina contact area and shear stress were calculated by computational fluid dynamics. Methods A numerical model of an emmetropic eye and a myopic eye with and without scleral band underwent a saccade of 50°/0.137 s. The vitreous chamber surface was divided into superior and inferior 180° sectors: lens, pre-equator, post-equator, and macula. SiO–retina contact was evaluated as a function of fill percentages between 80% and 90% for standing, 45° upward tilt, and supine patients. Maximum and average shear stress were calculated. Results Overall, SiO–retina contact ranged between 40% and 83%; fill percentage varied between 80% and 95%. Neither the encircling scleral band nor the staphyloma significantly affected the SiO–retina contact area, although the presence of a scleral band proved disadvantageous when gazing 45° upward. The inferior retina–SiO contact remained below 40% despite 95% SiO fill. The SS significantly increased at the scleral band indentation and decreased elsewhere. The staphyloma greatly reduced shear stress at the macula. Conclusions The presence of a myopic staphyloma reduces shear stress at the macula but does not alter SiO–retina contact significantly. The apposition of a 360° scleral band may reduce SiO–retina contact at least in some postures and increases the SS at the indentation. Translational Relevance Assessing SiO–retina contact when vitreous chamber geometry changes according to pathologic or iatrogenic modifications allows accurate prediction of real-life tamponade behavior and helps explain surgical outcomes.

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Study of wetting of the animal retinas by Water and organic liquids and its Implications for ophthalmology

Cited by 8 publications

References 38 publications

Physicochemical Properties of Explanted Silicone Oil After Use as an Intraocular Tamponade

Physicochemical Properties of Explanted Silicone Oil After Use as an Intraocular Tamponade

Adequate Silicone Oil Tamponade by Utilizing the Space of Anterior Segment for Complicated Retinal Detachment: Technique, Efficacy, and Safety

Silicone Oil Tamponade–Retina Contact in Highly Myopic Eyes With and Without Encircling Bands: A Computational Fluid Dynamics Study

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