The research aims to find out the crucial factors in the design phase of packaging products, which are related to the determination of environmental influences on sustainable materials. The paper presents the results of research into the influence of environmentally friendly cardboard and the separation of yellow offset ink on the optical properties of prints exposed to thermal aging without and with exposure to NO2. The samples were obtained under real conditions on a Roland 705 printing machine. The colorimetric characteristics of the print and its stability were determined in the research. The research is significant for graphic reproduction in the domain of testing the quality of the print itself, which is defined by certain raster characteristics. The research covers prints in 100%, 70% RTV, 50% RTV, and 30% RTV. The intensity of the tonal experience will depend on the interaction of the substrate with the raster and different types of inks in offset printing as a function of the experimental conditions. The ink characteristics of prints ∆L*, ∆a*, ∆b*, and ∆E were determined. The research results show that ink I1, with about 80% renewable raw materials, achieves the best stability under the specified experimental conditions.