When constructing reservoir simulation models of complex reservoirs, it is necessary to take into account the zonal heterogeneity of the filtration and reservoir properties and the influence of secondary processes on the filtration characteristics of the deposit. The underestimation of complex mining and geological conditions negatively affects the forecast for technological and economic indicators of the field development. The paper presents an approach to creating a reservoir simulation model of a complex reservoir based on the integration of different-scale research that allow us to judge the alternation of different types of reservoirs along the lateral and vertical lines. As a result, a refined reservoir permeability cube is constructed which allows us to take into account the influence of the fracturing and cavernous reservoir on the technological indicators of development.