Study on anti-diabetic activities of crude methanolic extracts of Loranthus micranthus (Linn.) sourced from five different host trees

Osadebe, PO; Okide, George B.; Akabogu, I.C.

doi:10.1016/j.jep.2004.06.029

Cited by 88 publications

(64 citation statements)

References 12 publications

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“…In Nigeria and some other parts of Africa, mistletoe has been used traditionally as antihypertensive and antidiabetic [6][7][8][9] . There have been reports on the phytochemical and antimicrobial properties of African mistletoe Loranthus micranthus [9] .…”

Section: Introductionmentioning

confidence: 99%

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Biochemical Changes in Wistar Rats on Oral Doses of Mistletoe (Loranthus micranthus)

Edem¹,

Usoh²

2009

American J. of Pharmacology and Toxicology

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Problem statement:To evaluate the effects of the water extract of the leaves of mistletoe (Loranthus micranthus) (traditionally used antidiabetic and antihypertensive) in male albino Wistar rats. Approach: The animals were divided into 4 groups (n = 6). Water extract of L. micranthus leaves was administered in graded doses of 0, 275, 551 and 827 mg kg −1 body weight (wt) of experimental animals for 21days. Blood samples were collected by cardiac puncture. The serum harvested was analyzed for some biochemical parameters, using assay kits. Results: There were no significant changes (p>0.05) in the levels of cholesterol, bilirubin, glucose, protein, urea, alkaline phosphatase and Aspartate Transaminase (AST). Alanine Transaminase (ALT) activities of the groups rats given 551 and 827 mg kg −1 body weight extracts (15.96 and 14.24 U L −1 respectively) showed significant decreases (p<0.05) when compared with the control (24.96 U L −1 ) and the group fed 275 mg kg −1 body weight of extract (16.19U L −1 ). Computed ALT/AST showed decreases in the test groups (0.77-0.78) when compared with the control (1.04). Conclusion: The results suggested no adverse biochemical changes being associated with the use of the extract or absence of hepatocellular damage at the investigated concentrations. Thus the use of the plant in the treatment and management of diabetes and hypertension should be encouraged.

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Section: Introductionmentioning

confidence: 99%

“…There have been reports on the phytochemical and antimicrobial properties of African mistletoe Loranthus micranthus [9] . However, information is scanty on the effects of the plant on biochemical parameters in experimental animals and on the possible risks associated with consumption of mistletoe extracts.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Changes in Wistar Rats on Oral Doses of Mistletoe (Loranthus micranthus)

Edem¹,

Usoh²

2009

American J. of Pharmacology and Toxicology

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“…[33] Water extract of seeds, administered intra-peritoneal to mice was active on Yoshida solid and ASC Sarcoma [34] but if administered subcutaneously was inactive on Yoshida ASC Sarcoma. [35] Panneerselvam et al in 2000 crystallized an agglutinin protein from the seeds of A. precatorius L. at room temperature with polyethylene glycol 8000 and showed that the protein had high antitumor activity.…”

Section: Anti-cancer Activitymentioning

confidence: 99%

Abrus Precatorius Linnaeus and Its Biological Activities - A Review

Mitra¹

2017

WJPPS

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“…Mistletoes are hemiparasitic shrubs that attach to the host stems in order to absorb mineral nutrients and water, although they provide their own carbohydrates through photosynthesis (Griggs, 1991). Because of this metabolic attachment to the host trees, their phytoconstituents and hence biological activities are strongly dependent on their respective hosts (Fukunaga et al, 1989;Osadebe et al, 2004). Additionally, recent studies revealed that the parasitic life of L. parasiticus (Fig.…”

Section: Botanical Description and Distributionmentioning

confidence: 99%

Phytochemistry and Biology of Loranthus parasiticus Merr, a Commonly Used Herbal Medicine

et al. 2014

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Loranthus parasiticus Merr (L. parasiticus) is a member of Loranthaceae family and is an important medicinal plant with a long history of Chinese traditional use. L. parasiticus, also known as Sang Ji Sheng (in Chinese), benalu teh (in Malay) and basokisei (in Japanese), is a semiparasitic plant, which is mostly distributed in the southern and southwestern regions of China. This review aims to provide a comprehensive overview of the ethnomedicinal use, phytochemistry and pharmacological activity of L. parasiticus and to highlight the needs for further investigation and greater global development of the plant's medicinal properties. To date, pharmacological studies have demonstrated significant biological activities, which support the traditional use of the plant as a neuroprotective, tranquilizing, anticancer, immunomodulatory, antiviral, diuretic and hypotensive agent. In addition, studies have identified antioxidative, antimutagenic, antiviral, antihepatotoxic and antinephrotoxic activity. The key bioactive constituents in L. parasiticus include coriaria lactone comprised of sesquiterpene lactones: coriamyrtin, tutin, corianin, and coriatin. In addition, two proanthocyanidins, namely, AC trimer and (þ)-catechin, have been recently discovered as novel to L. parasiticus. L. parasiticus usefulness as a medicinal plant with current widespread traditional use warrants further research, clinical trials and product development to fully exploit its medicinal value.

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Study on anti-diabetic activities of crude methanolic extracts of Loranthus micranthus (Linn.) sourced from five different host trees

Cited by 88 publications

References 12 publications

Biochemical Changes in Wistar Rats on Oral Doses of Mistletoe (Loranthus micranthus)

Biochemical Changes in Wistar Rats on Oral Doses of Mistletoe (Loranthus micranthus)

Abrus Precatorius Linnaeus and Its Biological Activities - A Review

Phytochemistry and Biology of Loranthus parasiticus Merr, a Commonly Used Herbal Medicine

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