2001
DOI: 10.1248/bpb.24.264
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Study on Anti-Oketsu Activity of Rhubarb. II. Anti-allergic Effects of Stilbene Components from Rhei undulati Rhizoma (Dried Rhizome of Rheum undulatum Cultivated in Korea).

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Cited by 72 publications
(46 citation statements)
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“…Earlier, the inhibitory activity of stilbene glycosides, the glucosyl residue of which attached at 3-or 3′-position, towards histamine release has been reported. 32,33) This is the first report of the inhibition of histamine release by stilbene glycoside which has glucosyl residue at its 4′-position. Ko et al reported that piceatannol (6) strongly inhibited histamine release.…”
Section: Resultsmentioning
confidence: 92%
“…Earlier, the inhibitory activity of stilbene glycosides, the glucosyl residue of which attached at 3-or 3′-position, towards histamine release has been reported. 32,33) This is the first report of the inhibition of histamine release by stilbene glycoside which has glucosyl residue at its 4′-position. Ko et al reported that piceatannol (6) strongly inhibited histamine release.…”
Section: Resultsmentioning
confidence: 92%
“…), jaundice, diarrhea and food poisoning, in addition to constipation. Although various individual pharmacological effects related to the above treatments, such as purgative activity, 2,3) anti-bacterial and anti-fungal activities, 4) anti-tumor activity, 5) anti-inflammatory and analgesic activities, 6,7) improvement of renal disorders, [8][9][10][11] improvement of nitrogen metabolism, 12,13) psychotropic activity, 14) anti-allergic effects, 15,16) anti-cholera toxin activity, 17,18) promoting blood circulation and removing blood stasis, 19) and the various involved active compounds have been reported, comprehensive chemical study of the composition of bioactive constituents of rhubarb has been rare. Kashiwada et al 20) set up a HPLC method to analyze almost all the phenolic compounds simultaneously, and reported that the majority of the compounds could be separated by a 0.05 M H 3 PO 4 solution-acetonitrile gradient elution system.…”
mentioning
confidence: 99%
“…Histamine Release Induced by Compound 48/80 and Ovalbumin from Rat Peritoneal Mast Cells The experiments were conducted according to the methods of Kubo et al 11,12) Intact rats and sensitized rats, which were immunized 24 h before test by intraperitoneal injection of 1 ml of rat anti-ovalbumin serum prepared in rat PCA, were used for compound 48/80 test and ovalbumin test, respectively. Mixed peritoneal cells were collected by peritoneal lavage and were purified by centrifugation through Ficoll density gradient.…”
mentioning
confidence: 99%