Study on antioxidant effect and chemical constituents of Taohong Siwu decoction

Liu, Li; Duan, Jin‐Ao; Tang, Yuping; Ma, Hongyue; Su, Shulan; Li, Xiaoxi

doi:10.4268/cjcmm20111209

Cited by 6 publications

(14 citation statements)

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Section: Introductionmentioning

confidence: 99%

“…Their anti-inflammatory activities, hemorheological improvement and ovarian regulation in rats with blood stasis were elucidated [8,9]. Moreover, SWDCF inhibited COX-2 enzyme and platelet aggregation in vitro [9,10]. The main constituents of SWDCF belong to several natural product groups, such as phenolic acids, phthalides, alkaloids, terpene glycosides, iridoid glycosides, flavones, and etc.…”

Section: Introductionmentioning

confidence: 99%

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Chemical fingerprinting and quantitative constituent analysis of Siwu decoction categorized formulae by UPLC-QTOF/MS/MS and HPLC-DAD

Cui

Zhou

et al. 2013

Chin Med

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BackgroundSiwu decoction categorized formulae (SWDCF) are widely used for treating gynecological diseases. This study aims to elucidate the differences of bioactive constituents in SWDCF by ultra-high performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC - QTOF - MS /MS) and HPLC-DAD.MethodsAn efficient method based on UPLC - QTOF - MS /MS was developed for identifying the chemical profiles of SWDCF. HPLC-DAD method was used for quantifying seven chemical markers in SWDCF.ResultsEighty four components were identified or characterized, including ten organic acids, thirty glycosides (monoterpene or iridoid or phenylpropanoids glycosides), fourteen lactones, eighteen flavonoids, and eleven alkaloids in the complex system. The datasets of tR-m/z pairs, ion intensities and sample codes were processed with supervised orthogonal partial least squared discriminant analysis to compare these decoction samples. After a clear classification was established, OPLS-DA was performed and 16 common components with relative quantity in SWDCF samples were determined. Gallic acid, protocatechuic acid, vanillic acid, caffeic acid, paeoniflorin, ferulic acid, and senkyunolide I were selected as the chemical markers to identify SWDCF by HPLC-DAD.ConclusionThe chemical profiles with 84 components in SWDCF, including monoterpene glycosides, acetophenones, galloyl glucoses, even some isomers in the complex system were characterized by UPLC–QTOF–MS/MS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical fingerprinting and quantitative constituent analysis of Siwu decoction categorized formulae by UPLC-QTOF/MS/MS and HPLC-DAD

Cui

Zhou

et al. 2013

Chin Med

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show abstract

“…Saponins work by stimulating the formation of new cells, or called Growth Factor. Causing the multiplication and growth of blood vessel endothelial cells, vascular smooth muscle cells and fibroblasts, causing cellular growth which ultimately repair damaged blood vessel walls [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34].…”

Section: Resultsmentioning

confidence: 99%

Bioactivity of Torch Ginger Umbut Extract (Etlingera elatior) Against Heal Wounds of Mice (Mus musculus)

Efendi

Sumarmin

Fadil

2020

Eksakta

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Torch ginger has a wide range of good antimicrobial, antioxidant, anticancer, larvicidal and repellent activities. Active compounds in Torch ginger that affect pharmacological activities are phenols, polyphenols, flavonoids, and terpenoids. Based on these ingredients Torch ginger can be used to heal wounds. This study aims to observe the effect of Torch ginger Umbut extract on wound healing in mice. This study hopes to add information about the effect of Torch ginger umbut extract on the healing of cuts in mice so that it can be another alternative for wound healing and can be a reference for other researchers. This study used a completely randomized design with 5 treatments and 3 replications. Tests carried out on adult male mice. The results showed that the optimal wound healing in P2 is treatment with 10% Torch ginger umbut extract which requires a range of wound healing 7-8 days. Based on these results, Torch ginger umbut extract can heal wounds.

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“…Compared with the control group, the THSWD group significantly reduced the division of mitochondria and the production of mitochondrial ROS (Luo et al, 2019), and both its ethanol extract and water extract had a scavenging effect on 1,1-diphenyl-2-picrylhydrazyl radical (Yang et al, 2011), thus inhibiting the oxidative stress reaction and reducing the damage of myocardial cells (Liu et al, 2011;Yu and Hong, 2016). THSWD can decrease the levels of serum creatine kinase (CK) and lactate dehydrogenase (LDH) in myocardial tissue during acute myocardial ischemia (Zhu and Zhang, 2003;Luo and Zhou, 2014), thus reducing myocardial cell necrosis.…”

Section: Anti-oxidationmentioning

confidence: 99%

Effects and Mechanisms of Taohong Siwu Decoction on the Prevention and Treatment of Myocardial Injury

Cui

Guo

2022

Front. Pharmacol.

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Taohong Siwu decoction (THSWD) is one of the classic prescriptions for promoting blood circulation and removing blood stasis. With the continuous in-depth excavation in basic and clinical research, it has been found that THSWD has made greater progress in the prevention and treatment of cardiovascular diseases. Mechanisms of the current studies have shown that it could prevent and treat the myocardial injury by inhibiting inflammatory reaction, antioxidant stress, inhibiting platelet aggregation, prolonging clotting time, anti-fibrosis, reducing blood lipids, anti-atherosclerosis, improving hemorheology and vascular pathological changes, regulating related signal pathways and other mechanisms to prevent and treat the myocardial injury, so as to protect cardiomyocytes and improve cardiac function. Many clinical studies have shown that THSWD is effective in the prevention and treatment of cardiovascular diseases related to myocardial injuries, such as coronary heart disease angina pectoris (CHD-AP), and myocardial infarction. In clinical practice, it is often used by adding and subtracting prescriptions, the combination of compound prescriptions and combinations of chemicals and so on. However, there are some limitations and uncertainties in both basic and clinical research of prescriptions. According to the current research, although the molecular biological mechanism of various active ingredients needs to be further clarified, and the composition and dose of the drug have not been standardized and quantified, this study still has exploration for scientific research and clinical practice. Therefore, this review mainly discusses the basic mechanisms and clinical applications of THSWD in the prevention and treatment of the myocardial injury caused by CHD-AP and myocardial infarction. The authors hope to provide valuable ideas and references for researchers and clinicians.

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Study on antioxidant effect and chemical constituents of Taohong Siwu decoction

Cited by 6 publications

References 0 publications

Chemical fingerprinting and quantitative constituent analysis of Siwu decoction categorized formulae by UPLC-QTOF/MS/MS and HPLC-DAD

Chemical fingerprinting and quantitative constituent analysis of Siwu decoction categorized formulae by UPLC-QTOF/MS/MS and HPLC-DAD

Bioactivity of Torch Ginger Umbut Extract (Etlingera elatior) Against Heal Wounds of Mice (Mus musculus)

Effects and Mechanisms of Taohong Siwu Decoction on the Prevention and Treatment of Myocardial Injury

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