Study on antitumor activity of metal-based diketone complexes

Zhang, Kaizhi; Cui, Shusen; Wang, Jingjing; Wang, Xiaohong; Li, Rui

doi:10.1007/s00044-011-9618-0

Cited by 10 publications

(9 citation statements)

References 16 publications

(16 reference statements)

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“…Therefore, we synthesized β-diketone-cobalt complexes [Co(acac)2(H 2 O)2, CoAc2]. It has been reported that CoAc2 has cytotoxic effects on liver cancer, ovarian cancer, glioma, and other tumor cells [23,24]. CoAc2 can inhibit DNA synthesis in tumor cells and induce S-phase arrest.…”

Section: Introductionmentioning

confidence: 99%

Beta-Diketone–Cobalt Complexes Sensitize Glioma Stem Cells to Temozolomide Partly Through the ERK-MGMT Pathway

Zhang

Lang

Mang

2021

Preprint

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Glioblastoma multiforme is characterized by high invasiveness, multidrug resistance, and inevitable recurrence, and current standard treatment regimens are not curative. Even if most glioma cells are eliminated by chemotherapy and radiotherapy, glioma stem cells can survive and differentiate into new tumor cells, thereby triggering tumor recurrence and drug resistance. Therefore, inhibiting tumor invasiveness, reversing drug resistance, and effectively ablating glioma stem cells are critical for improving the prognosis of glioblastoma multiforme. Previous studies reported that the combination of β-diketone–cobalt complexes (CoAc2) and temozolomide (TMZ) has synergistic inhibitory effects on glioma cells. Therefore, we compared cell proliferation, colony-forming capacity, cell migration, and invasion of TMZ-resistant glioma cells and corresponding glioma stem cells after treatment with CoAc2 and/or TMZ. We also explored the underlying mechanism by which CoAc2 sensitizes cells to TMZ through transcriptome sequencing and related signal pathway blockade. We found that CoAc2 significantly increased the inhibitory effect of TMZ on the proliferation, colony formation, migration, invasion, and survival of drug-resistant stem cells. By downregulating ERK pathway activity, CoAc2 inhibited the expression of O6-methylguanine-DNA methyltransferase and eventually sensitized drug-resistant glioma cells to TMZ. In conclusion, the combined use of CoAc2 and TMZ can reverse TMZ resistance and significantly enhance its inhibitory effect on the malignant phenotype of glioma cells and glioma stem cells.

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Section: Introductionmentioning

confidence: 99%

Beta-Diketone–Cobalt Complexes Sensitize Glioma Stem Cells to Temozolomide Partly Through the ERK-MGMT Pathway

Zhang

Lang

Mang

2021

Preprint

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“…1−3 Also, of particular interest are discovered antitumor properties of cobalt(II) acetylacetonate and its derivatives. 4 These complexes more effectively inhibit growth of glioma cells compared to the well-known cytostatic fluorouracil. 5 Obviously, cobalt(II) acetylacetonate has a high application potential.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, cobalt(II) acetylacetonate has been widely used in macromolecular engineering. This is due to the fact that it is a highly effective mediator in the controlled radical polymerization of vinyl monomers. − Also, of particular interest are discovered antitumor properties of cobalt(II) acetylacetonate and its derivatives . These complexes more effectively inhibit growth of glioma cells compared to the well-known cytostatic fluorouracil .…”

Section: Introductionmentioning

confidence: 99%

Low-Temperature Heat Capacity and Thermodynamic Functions of Tetrameric Cobalt(II) Acetylacetonate

Bespyatov

2020

J. Chem. Eng. Data

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Low-temperature heat capacity of tetrameric cobalt(II) acetylacetonate (tetrakis[bis(2,4-pentanedionato)cobalt(II)], [Co(C 5 H 7 O 2 ) 2 ] 4 ) was measured by an adiabatic method in a temperature range from 13.49 to 310.31 K. No phase transition-associated anomalies in the functional behavior of the heat capacity were detected in the entire tested temperature range. The obtained data were used to calculate the Debye characteristic temperature and integral thermodynamic functions (entropy, enthalpy, and reduced Gibbs energy) in a temperature range of 0 to 310 K. The absolute entropy values were used to calculate the formation entropy of [Co(C 5 H 7 O 2 ) 2 ] 4 at T = 298.15 K. A correlation was found between the unit cell volume, normalized to the number of molecules in this cell, and the heat capacity at T = 298.15 K.

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“…β-diketone-cobalt complexes have been shown to suppress SMMC-7721 and SK-OV-3 tumor cell viability and interact with λ-DN (6); however, the molecular mechanisms of β-diketone-cobalt complexes against tumors remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…β-diketone-cobalt complexes are polyoxometalates containing cobalt and traditional methods have been modified for the synthesis ( 5 ). β-diketone-cobalt complexes have been shown to suppress SMMC-7721 and SK-OV-3 tumor cell viability and interact with λ-DN ( 6 ); however, the molecular mechanisms of β-diketone-cobalt complexes against tumors remain unclear.…”

Section: Introductionmentioning

confidence: 99%

β-diketone-cobalt complexes inhibit DNA synthesis and induce S-phase arrest in rat C6 glioma cells

et al. 2013

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β-diketone-cobalt complexes, a family of newly synthesized non-platinum metal compounds, exhibit potential antitumor activity; however, the antitumor mechanism is unclear. The current study investigated the mechanism by which β-diketone-cobalt complexes inhibit rat C6 glioma cell proliferation. It was found that β-diketone-cobalt complexes suppress rat C6 glioma cell viability in a dose-dependent manner (3.125–100 μg/ml). In rat C6 glioma cells, the IC50 value of β-diketone-cobalt complexes was 24.7±3.395 μg/ml and the IC10 value was 4.37±1.53 μg/ml, indicating a strong inhibitory effect. Further investigation suggested that β-diketone-cobalt complexes inhibit rat C6 glioma cell proliferation, which is associated with S-phase arrest and DNA synthesis inhibition. During this process, β-diketone-cobalt complexes decreased cyclin A expression and increased cyclin E and p21 expression. In addition, β-diketone-cobalt complexes exhibit a stronger antitumor capability than the antineoplastic agent, 5-fluorouracil.

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Study on antitumor activity of metal-based diketone complexes

Cited by 10 publications

References 16 publications

Beta-Diketone–Cobalt Complexes Sensitize Glioma Stem Cells to Temozolomide Partly Through the ERK-MGMT Pathway

Beta-Diketone–Cobalt Complexes Sensitize Glioma Stem Cells to Temozolomide Partly Through the ERK-MGMT Pathway

Low-Temperature Heat Capacity and Thermodynamic Functions of Tetrameric Cobalt(II) Acetylacetonate

β-diketone-cobalt complexes inhibit DNA synthesis and induce S-phase arrest in rat C6 glioma cells

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