Study on clinical and genetic characteristics of male patients with non-obstructive azoospermia

Abstract

We examined 501 patients with non - obstructive azoospermia to evaluate clinical, subclinical, and genetic characteristics. The results show that the average age of patients in the study was 29.8 ± 5.5 years. Primary infertility accounts for the majority, with a rate of 90.3%. There was 38.6% of patients had a history of mumps orchitis. The average levels of FSH, LH, testosterone were 31.6 ± 16.5 mIU/mL, 15.5 ± 10 mIU/mL and 12.8 ± 7.13 nmol/L, respectively. The prevalence of chromosomal abnormalities was 30.7%. Of these, the sex chromosome aneuploidy with 47,XXY karyotype (Klinefelter syndrome) accounted for 27.3%. The incidence of AZF microdeletion was 13.8%. Of these, AZFc deletion was the most common at the rate of 42.1%, AZFa deletion, which accounted for 2.6%, were the least prevalent, and the frequency of AZFd deletion was 5.3%. However, there was no solitary AZFb deletion, which combined with other AZF deletions with 34.2%. Our research shows that mumps orchitis and chromosomal abnormalities are the leading causes of azoospermia. Screening for genetic abnormalities plays an important role in infertile patients with non - obstructive azoospermia.

Testicular histopathology and associated factors in men with non-obstructive azoospermia

“…2 Data from Hanoi Medical University Hospital showed that azoospermia affected 20.8% of patients who sought consultation for male infertility at the Department of Andrology and Sexual Medicine. 3 Among the etiology of azoospermia, non-obstructive azoospermia (NOA) is the most severe form due to the failure of spermatogenesis and in the past, the only option for fathering a child is donor sperm. However, with the advances of assisted reproductive technique (ART) and microsurgery, the use of micro testicular sperm extraction (microTESE) followed by intracytoplasmic injection (ICSI) has brought the opportunity for these patients to have their own children.…”