Study on clinical effect of 30% nitrous oxide and oxygen mixture (Anesoxin-30) in oral surgery

Murase, Masao; Sato, Masashi; Kokita, Y; Shima, K; Tokiwa, Nobuo; Hasegawa, Shiro; Yatabe, Yuji; Ohashi, Yasushi; Kanri, Tomio; Suzuki, Yoshio; Nomura, Okiyasu; Sekiyama, Saburo; Komoribayashi, Naoyuki; Seki, S; Mori, Yutaka; Tomita, Kinai; Shinya, Noboru; Murakami, Tadakatsu; Goda, Shigemi; Fukushima, Kazuaki; Sasaki, Motomasa; Tsubahara, Shigeru; Yuki, Kazuo; Hayatsu, Yoshikazu

doi:10.5794/jjoms.21.649

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…The LG-induced sedation is a simple and fairly safe method for humans; hence it is used to alleviate anxiety and fear [6][7][8][9][10] . However, in addition to the sedative effect, the method was reported to increase the threshold value of sensation in the oral cavity of patients; for example, alleviating aches and decreasing the vomiting reflex [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Characteristics of sensing lower-jaw-position in patients with cerebral palsy during laughing gas-induced sedation

Yoshida

Nakajima

Uchida

et al. 2005

Pediatric Dental Journal

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To clarify the effects of the applied during sedation with nitrous oxide (hereafter referred to as laughing gas) on the ability of muscles attached to the lower jaw to sense lower-jaw-position and on the sensation of muscle spindles attached to the lower jaw in patients with cerebral palsy (CP) using healthy adult subjects without functional abnormalities of the jaws and oral cavities as control subjects (hereafter referred to as healthy subjects). Experiments were performed under the following conditions: for each subject, before the inhalation of laughing gas (LG) and oxygen (air-inhalation condition: referred to as without LG inhalation) and during the inhalation of LG and oxygen (inhalation condition of LG and oxygen under LG-induced sedation: referred to as during LG inhalation). Subjects in the experiments were eight CP patients and eight healthy people as controls. The ability to discriminate lowerjaw-position was estimated by asking the subjects to determine whether the diameter of a test stick was larger or smaller than that of a reference stick after performing the following tasks: a) holding a reference stick between the central teeth of their upper and lower jaws for 5 s, and b) replacing the reference stick with a test stick and holding it at the same position for 5 s, and the test stick was then removed. The following findings were obtained. 1) In comparing discrimination ability in the absence of LG-induced sedation and that during LG-induced sedation of healthy control subjects, the rate of mis-estimation (RME) was significantly larger during LG-induced sedation than in the absence of LG-induced sedation for a test stick diameter (10.5 mm or 11.0 mm) larger than the reference stick diameter (10.0 mm) (PϽ0.05). No significant differences were observed for any other test sticks (PϾ0.05). 2) In comparing discrimination ability in the absence of LG-induced sedation and that during LG-induced sedation of CP patients, RME was significantly smaller during LG-induced sedation than in the absence of LG-induced sedation, when the test stick diameter (9.5 mm) was smaller than the reference stick diameter (PϽ0.05). No significant differences were observed for any other test sticks (PϾ0.05). These results indicate that neural functions are inhibited at the upper level of the central nervous system in CP patients, leading to the attenuation of sustained increase in muscle tonus that is characteristic of CP patients. In summary, it seems that the LG has some inhibitory effect on the activity of ␥-motor neurons innervating muscle spindles attached to the lower jaw via the upper level of the central nervous system and that this inhibitory effect contributes to an improvement in the discrimination ability.

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Section: Introductionmentioning

confidence: 99%

Characteristics of sensing lower-jaw-position in patients with cerebral palsy during laughing gas-induced sedation

Yoshida

Nakajima

Uchida

et al. 2005

Pediatric Dental Journal

View full text Add to dashboard Cite

show abstract

“…The LG-induced sedation is a simple and fairly safe method for humans; hence it is used to alleviate anxiety and fear [13][14][15][16][17] . However, in addition to the sedative effect, the method was reported to increase the threshold value of sensation in the oral cavity of patients; for example, alleviating aches and decreasing the vomiting reflex [18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Effects of vibration stimulus on lower-jaw-position sensation in patients with cerebral palsy during inhalation of laughing gas

Yoshida

Nakajima

Uchida

et al. 2005

Pediatric Dental Journal

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To clarify the effects of a vibration stimulus applied during sedation with nitrous oxide (hereafter referred to as laughing gas) on the ability of muscles attached to the lower jaw to sense lower-jaw position and on the sensation of muscle spindles attached to the lower jaw in patients with cerebral palsy (CP) using healthy adult subjects without functional abnormalities of the jaws and oral cavities as control subjects (hereafter referred to as healthy subjects). Experiments were performed under the following conditions: for each subject, before the application of the vibration stimulus (referred to as Spre) and after the application of the vibration stimulus (Spost); before the inhalation of laughing gas (LG) and oxygen (air-inhalation condition: referred to as without LG inhalation) and during the inhalation of LG and oxygen (inhalation condition of LG and oxygen under LG-induced sedation: referred to as during LG inhalation). Subjects in the experiments were eight CP patients and eight healthy people as controls. The ability to discriminate lower-jaw position was estimated by asking the subjects to determine whether the diameter of a test stick was larger or smaller than that of a reference stick after performing the following tasks: a) holding a reference stick between the central teeth of their upper and lower jaws for 5 s, and b) replacing the reference stick with a test stick and holding it at the same position for 5 s, and the test stick was then removed. The following findings were obtained. 1) In comparing the ability of healthy subjects to discriminate between Spre and Spost during LG inhalation using different test sticks, when the test stick diameter was 9.5 mm (smaller than the reference stick diameter), the rate of mis-estimation (RME) for Spost was significantly larger than that for Spre (PϽ0.05). No significant differences were observed for any other test sticks. 2) In comparing the ability of CP patients to discriminate between Spre and Spost during LG inhalation using different test sticks, when the test stick diameter was 9.5 mm (smaller than the reference stick diameter), the RME for Spost was significantly smaller than that for Spre (PϽ0.05). No significant differences were observed for any other test sticks. These results suggest the following: the combination of LG for sedation with vibration stimulus further inhibits neuronal functions at the upper level of the central nervous system in CP patients, compared with cases in which each variable is applied separately, and the combination also inhibits the sustained increase in muscle tonus, which is characteristic of CP patients. LG reduces the activity of ␥-motor neurons via the upper level of the central nervous system. In addition, tonic vibration reflex (TVR) develops due to the vibration stimulus, which increases the threshold value of sensitive muscle sensation and decreases the activity of ␥-motor neurons, and furthermore decreases the activity of muscle spindles attached to the lower jaw. Consequently, a tendency toward increased ab...

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Study on clinical effect of 30% nitrous oxide and oxygen mixture (Anesoxin-30) in oral surgery

Cited by 2 publications

References 7 publications

Characteristics of sensing lower-jaw-position in patients with cerebral palsy during laughing gas-induced sedation

Characteristics of sensing lower-jaw-position in patients with cerebral palsy during laughing gas-induced sedation

Effects of vibration stimulus on lower-jaw-position sensation in patients with cerebral palsy during inhalation of laughing gas

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