Study on clinical profile of dengue in a tertiary care hospital of Nepal

Gyawali, Kenopama; Rijal, Reisha; Regmi, Shanti; Sedhai, Sabina; Adhikari, Shital

doi:10.3126/jcmc.v8i1.23719

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…This finding was similar to the study done in Nepal, India, Taiwan and Malaysia. [7][8][9][10][11] The median age of presentation was 29 years. The older age group represented a minority (<5%) of cases.…”

Section: Discussionmentioning

confidence: 99%

Admitted Dengue Cases among the Adult Dengue Positive Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Dhungana

Banstola

Banjara³

2022

J Nepal Med Assoc

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Introduction: Dengue is an infectious disease. This disease is prevalent mainly in the terai belts of Nepal. But in the last few years, the cases are in increasing trend in the hilly areas of Nepal. The aim of this study was to find out the prevalence of admitted dengue cases among adult dengue-positive cases in a tertiary care centre. Methods: This was a descriptive cross-sectional study done at a tertiary teaching hospital after obtaining ethical approval from the Institutional Review Committee (Reference number: 063/2077/2078). Convenience sampling was used. The data of serologically confirmed dengue cases, during the period of 1 August 2019 to 1 December 2019, of ages above 15 years, were collected from the hospital records. Point estimate and 95% Confidence Interval were calculated. Results: Out of 922 adult dengue-positive patients, 347 (37.63%) (36.04-39.22, 95% Confidence Interval) were admitted. Among them, 154 (44.38%) cases were seen during the month of September. A total of 264 (76.08%) were the inhabitants of the Kaski district. A total of one hundred seventy eight (51.29%) cases were males. The most common symptoms seen were fever among 335 (96.54%) patients and headache among 141 (40.63%) patients. Leukopenia was seen in 192 (55.33%) patients and thrombocytopenia was seen in 165 (47.55%) of the admitted cases. Conclusions: The prevalence of admitted dengue cases was higher as compared to other studies done in similar settings.

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Section: Discussionmentioning

confidence: 99%

Admitted Dengue Cases among the Adult Dengue Positive Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Dhungana

Banstola

Banjara³

2022

J Nepal Med Assoc

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“…Research on dengue has been limited in Nepal and only few papers are available. Limited research mainly focused on terai belts and mainly on serological and demographic characteristics (4)(5)(6)(7). This study focuses on all aspects including the laboratory parameters which will help to estimate the morbidity to a deeper extent which ultimately burdens the economical constraint of the individual, society and the country.…”

Section: Modes Of Transmission Are Variable Butmentioning

confidence: 99%

Clinical and haematological profile of dengue among adult patients at a tertiary care hospital in Pokhara

Dhungana

Banstola

Banjara

2022

Preprint

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IntroductionDengue is an important infectious disease. This disease is prevalent in the terai belts of Nepal mainly. But in the last few years, the cases are in increasing trend in the hilly areas of Nepal also. Hence this study was done in an aim to study the clinical and haematological profile of the dengue cases.MethodsThis was a retrospective cross-sectional quantitative study done at a tertiary teaching hospital of Pokhara, Nepal after obtaining ethical approval from the institutional ethical committee. The data of serologically confirmed dengue cases, during the period of August 2019 to December 2019, of age above 15 years, were collected and analysed using SPSS 20. Descriptive analysis in terms of mean, median, percentage as well as t-test for nominal and chi-square tests were used to compare different parameters. P-value≤ 0.05 was considered statistically significant.ResultsOut of 922 patients, approximately one-half (50.5%) cases were seen during the month of September. Most (82.8%) were the inhabitants of Kaski district. Median age of presentation was 29 years with slightly more cases of males (52.4%). Three hundred and forty seven patients were admitted. Fever (96.5%) and headache (40.6%) were the most common symptoms on presentation of admitted cases. Leukopenia (55.3%) was more common than thrombocytopenia (47.6%) in the admitted cases. On comparison between admitted patients with warning signs and those without signs, no significant variation was seen in terms of age, total leukocyte count and total platelet count.ConclusionDengue is common in young population. Fever, headache and gastrointestinal symptoms are common among dengue patients. Leukopenia and thrombocytopenia are common laboratory features of dengue.

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Dengue: Rapid Diagnostic Testing in a Tertiary Care Setting in Butwal, Nepal

Khadka¹,

Neupane²,

Chaudhary³

et al. 2023

J. Pure Appl. Microbiol.

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Dengue virus (DENV) is spread mostly by biting by the infected female mosquitoes of the species Aedes aegypti, that are commonly found in tropical and subtropical zones of globe. Some studies have shown that nearly fifty percent of the globe are susceptible to DENV. Most infections by DENV are asymptomatic. Clinical infections vary from mild fever to serious diseases including hemorrhagic fever and shock syndrome. The main objective of this study was to estimate DENV infection by rapid diagnostic (RDTs) kit methods in a tertiary care setting. This retrospective study was done at Crimson Hospital, Butwal, Nepal from June to November 2019. Serum samples of all dengue fever suspected patients were tested for DENV antigen as Dengue nonstructural protein 1(NS1) and DENV specific antibodies as IgM and IgG by using World Health Organization Good Manufacturing Practices (GMP) certified rapid solid phase immunochromatographic method. All laboratory test results were tabulated by using MS-Excel and analyzed by statistical package for the Social Sciences software version 20. Out of 821 samples tested, 518 were positive, including 322 (62.16%) reactive for dengue NS1 Protein, 121 (23.35%) for IgM, 62 (11.96%) for IgG and 13 (2.50%) were positive for both IgG and IgM antibodies. Our study showed high prevalence of dengue infection during monsoon to post-monsoon and the infection rate was higher in males (71.72%) than in females (53.36%). According to our findings, DENV infection is prevalent in Butwal, Nepal. Early diagnosis, better case management, faster public health response and effective health policy towards the control of mosquito vectors may reduce the dengue burden and must be implemented in Nepal.

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Study on clinical profile of dengue in a tertiary care hospital of Nepal

Cited by 3 publications

References 13 publications

Admitted Dengue Cases among the Adult Dengue Positive Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Admitted Dengue Cases among the Adult Dengue Positive Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Clinical and haematological profile of dengue among adult patients at a tertiary care hospital in Pokhara

Dengue: Rapid Diagnostic Testing in a Tertiary Care Setting in Butwal, Nepal

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