In order to improve the crushing efficiency of high-pressure roller mill and reduce energy consumption, the optimal parameter combination of high-pressure roller mill is sought, GM160-140 high-pressure roller mill is taken as the research object, and the discrete element simulation calculation model of high-pressure roller mill is established to simulate the crushing process. Taking the roll surface pressure, productivity, and the proportion of discharge particle diameter as the performance evaluation indexes, the simulation data are used to analyze the influence of each working condition parameter of the high-pressure roller mill on its performance law. Through the entropy weighting method to determine the weights of high-pressure roller mill productivity, roll surface pressure, the proportion of discharge particle diameter, and through the extreme difference analysis to get the optimal parameter combination. Minitab software is used to carry out the response surface method (RSM) experimental design, the optimal parameter combinations are derived from the optimization using the response surface apparatus, the optimal parameter combinations derived from the two optimization methods are compared and analyzed, and ultimately it is concluded that the optimization of the response surface is the global optimal, and the optimal parameter combinations are as follows: the roller speed is 2.50 rad/s, the roller gap is 28.87 mm, and the feed size is 31.97 mm, Under the above optimal parameters, the roll surface pressure is 150450.00 N, the productivity is 1268.00t/h, the percentage of the material less than 6 mm is 58.14%, so as to achieve the purpose of optimizing the parameters of the high-pressure roller mill, It is of significance to save resources and respond to the national green development and intelligent development.