“…The available methods for depolymerizing PPC can be classified as: (1) acid hydrolysis with nucleophiles, such as phloroglucinol (Matthews et al 1997 ) and benzyl mercaptane (Gu et al 2002 ), while the depolymerizing reagents were not allowed to apply in food, pharmaceutical and cosmetic industry due to the toxicity of nucleophiles; (2) acid hydrolysis with expensive chain breakers, such as catechin (CA), epicatechin (EC), and epicatechin-3-O-gallate (ECG) (Liu et al 2013 ); (3) acid hydrolysis with sulphurous acid, which produced the procyanidins with higher yield and purity, but its potential environmental impact is a big problem (Luo et al 2018 ); (4) acid salt hydrolysis, such as sodium bisulfite, which also confronts the serious environmental problem (Lin et al 2014 ); (5) alkaline hydrolysis, which only converted 6% of the PPC into OPC (White et al 2010 ); (6) hydrogenolysis, which needs dangerous operating conditions and requires expensive catalysts (Li et al 2015 ). Taken together, the earlier reported methods indicated some drawbacks for their industrial applications, such as toxic byproducts, low hydrolyzing rate, dangerous operating conditions, high cost-consumption and environmental pollution (Wu et al 2019 ).…”