Study on effects of miR-141-3p in proliferation, migration, invasion and apoptosis of colon cancer cells by inhibiting Bcl2

Tong, Shiyu; Zhang, X Y; Guo, Hongyan; Yang, Jifang; Qi, Yi; Lu, S

doi:10.1007/s12094-021-02653-2

Cited by 13 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yang and colleagues revealed the upregulation mechanism of miR-141-3p in endometrial cancer and predicted the key role of miR-141-3poverexpression in carcinogenesis and prognosis [ 27 ]. In addition, miR-141-3p was confirmed to be differentially expressed as well in human diseases such as polycystic ovary syndrome [ 28 ], clear cell renal cell carcinoma [ 29 ], and colorectal cancer [ 30 ]. The above studies demonstrated the ability of ATP2B1-AS1 to affect the development of different types of tumors and the prognosis of patients through multiple mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Regulation of overexpression lncRNA ATP2B1-AS1 on lung adenocarcinoma progression

Chen,

Huang,

Jin

2024

J Cardiothorac Surg

View full text Add to dashboard Cite

Background LncRNA ATP2B1-AS1 (ATP2B1-AS1) is involved in the occurrence and development of various diseases, while the relationship between lung adenocarcinoma (LUAD) and ATP2B1-AS1 is unclear. This study was to investigate the expression of ATP2B1-AS1 in LUAD and its influence on survival and prognosis of patients. Methods LUAD tissue samples from patients participating in this study were collected, and the expression levels of ATP2B1-AS1 and miR-141-3p in LUAD sampleswere detected by real-time quantitative polymerase chain reaction (RT-qPCR). The effect of ATP2B1-AS1 on the growth of A549 cells was investigated through cell counting kit-8 (CCK-8) and transwell experiments. Besides, the prognostic value of ATP2B1-AS1 in LUAD was assessed via Kaplan-Meier curve and multivariate Cox regression. Results ATP2B1-AS1 was downregulated in LUAD tissues and cells, whereas miR-141-3p was upregulated. After pcDNA3.1-ATP2B1-AS1 was transfected into A549 cells, the proliferation ability of A549 cells was decreased, and the migration level and invasion of A549 cells were also inhibited. High expression of ATP2B1-AS1 sponge miR-141-3p exerted prognostic value. Conclusions ATP2B1-AS1 sponge miR-141-3p alleviated the progression of LUAD, and ATP2B1-AS1 may be deemed as a prognostic marker for LUAD.

show abstract

Section: Discussionmentioning

confidence: 99%

Regulation of overexpression lncRNA ATP2B1-AS1 on lung adenocarcinoma progression

Chen,

Huang,

Jin

2024

J Cardiothorac Surg

View full text Add to dashboard Cite

show abstract

“…Thanks to the development of molecular biology, an increasing number of studies noticed the significance of miRNAs in human diseases. MiR-141-3p was a functional miRNA located on chromosome 12q 13.31 and has been identified as a reliable biomarker for various human malignancies, such as colon cancer, hepatocellular carcinoma, and clear cell renal cell carcinoma (Liep et al 2016;Tong et al 2021;Wang et al 2023). Additionally, miR-141-3p was also previously demonstrated to express in lung and regulate acute lung injury and lung fibroblasts (Jin et al 2018;Xia et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Predictive Significance of Serum MiR-141-3p in Acute Respiratory Distress Syndrome Patients with Pulmonary Fibrosis

Long,

Zhang,

Yang

et al. 2024

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…miR-141 is reported to affect angiogenesis, proliferation, and metastasis in colon cancer and nasopharyngeal carcinoma (Dong et al, 2019;Tong et al, 2021). Although its role in PCa is yet to be defined, studies have reported miR-141 to be commonly present in the blood of PCa patients (Yaman Agaoglu et al, 2011).…”

Section: Mir-141-5pmentioning

confidence: 99%

Urinary extracellular vesicles miRNA—A new era of prostate cancer biomarkers

et al. 2023

View full text Add to dashboard Cite

Prostate cancer is the second most common male cancer worldwide showing the highest rates of incidence in Western Europe. Although the measurement of serum prostate-specific antigen levels is the current gold standard in PCa diagnosis, PSA-based screening is not considered a reliable diagnosis and prognosis tool due to its lower sensitivity and poor predictive score which lead to a 22%–43% overdiagnosis, unnecessary biopsies, and over-treatment. These major limitations along with the heterogeneous nature of the disease have made PCa a very unappreciative subject for diagnostics, resulting in poor patient management; thus, it urges to identify and validate new reliable PCa biomarkers that can provide accurate information in regard to disease diagnosis and prognosis. Researchers have explored the analysis of microRNAs (miRNAs), messenger RNAs (mRNAs), small proteins, genomic rearrangements, and gene expression in body fluids and non-solid tissues in search of lesser invasive yet efficient PCa biomarkers. Although the presence of miRNAs in body fluids like blood, urine, and saliva initially sparked great interest among the scientific community; their potential use as liquid biopsy biomarkers in PCa is still at a very nascent stage with respect to other well-established diagnostics and prognosis tools. Up to date, numerous studies have been conducted in search of PCa miRNA-based biomarkers in whole blood or blood serum; however, only a few studies have investigated their presence in urine samples of which less than two tens involve the detection of miRNAs in extracellular vesicles isolated from urine. In addition, there exists some discrepancy around the identification of miRNAs in PCa urine samples due to the diversity of the urine fractions that can be targeted for analysis such as urine circulating cells, cell-free fractions, and exosomes. In this review, we aim to discuss research output from the most recent studies involving the analysis of urinary EVs for the identification of miRNA-based PCa-specific biomarkers.

show abstract

Study on effects of miR-141-3p in proliferation, migration, invasion and apoptosis of colon cancer cells by inhibiting Bcl2

Cited by 13 publications

References 34 publications

Regulation of overexpression lncRNA ATP2B1-AS1 on lung adenocarcinoma progression

Regulation of overexpression lncRNA ATP2B1-AS1 on lung adenocarcinoma progression

Diagnostic and Predictive Significance of Serum MiR-141-3p in Acute Respiratory Distress Syndrome Patients with Pulmonary Fibrosis

Urinary extracellular vesicles miRNA—A new era of prostate cancer biomarkers

Contact Info

Product

Resources

About