Study on electrical current variations in electromembrane extraction process: Relation between extraction recovery and magnitude of electrical current

Rahmani, Turaj; Rahimi, Atyeh; Nojavan, Saeed

doi:10.1016/j.aca.2015.11.024

Cited by 34 publications

(13 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given that 2‐ethylhexanol is cheaper than NPOE, it was selected as optimal SLM for further studies. Before it was shown that 2‐ethylhexanol and NPOE has similar extraction behavior, when they were used as SLM in EME procedure .…”

Section: Resultsmentioning

confidence: 99%

Investigation of the continuous flow of the sample solution on the performance of electromembrane extraction: Comparison with conventional procedure

Nojavan

Sirani

Asadi

2017

J of Separation Science

Self Cite

View full text Add to dashboard Cite

In this study, electromembrane extraction from a flowing sample solution, termed as continuous-flow electromembrane extraction, was developed and compared with conventional procedures for the determination of four basic drugs in real samples. Experimental parameters affecting the extraction efficiency were further studied and optimized. Under optimum conditions, linearity of continuous-flow procedure was within 8.0-500 ng/mL, while it was wider for conventional procedures (2.0-500 ng/mL). Moreover, repeatability (percentage relative standard deviation) was found to range between 5.6 and 10.4% (n = 3) for the continuous-flow procedure, with a better repeatability than that of conventional procedures (2.3-5.5% (n = 3)). Also, for the continuous-flow procedure, the estimated detection limit (signal-to-noise ratio = 3) was less than 2.4 ng/mL and extraction recoveries were within 8-10%, while the corresponding figures for conventional procedures were less than 0.6 ng/mL and 42-60%, respectively. Thus, the results showed that both continuous flow and conventional procedures were applicable for the extraction of model compounds. However, the conventional procedure was more convenient to use, and thus it was applied to determine sample drugs in real urine and wastewater samples.

show abstract

Section: Resultsmentioning

confidence: 99%

Investigation of the continuous flow of the sample solution on the performance of electromembrane extraction: Comparison with conventional procedure

Nojavan

Sirani

Asadi

2017

J of Separation Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…Besides, low viscosity, the ability to making dipole-dipole interactions, low solubility in water, and high boiling points are central other features for the SLM [16]. Some prior studies reported very close results for EME of the basic drugs based on 2-ethyl hexanol in comparison with 2-nitrophenyl octyl ether (NPOE), both as SLMs [17,18]. Furthermore, the price of 2-ethyl hexanol is considerably lower than NPOE, and it is more accessible.…”

Section: Optimization Of Extraction Proceduresmentioning

confidence: 99%

An investigation on the effect of filtration and dilution of biological samples on electromembrane extraction efficiency: Determination of basic drugs in plasma and urine samples

Mahdavi

Nojavan

Asadi

2020

Separation Science Plus

Self Cite

View full text Add to dashboard Cite

In the present work, the impact of dilution and filtration of biological samples (plasma and urine) using ultra-centrifugal filters were analytically assessed as pretreatment steps before the electromembrane extraction. Pseudoephedrine, lidocaine, propranolol, and ketoconazole were chosen as the basic model drugs. They were analyzed by using high-performance liquid chromatography coupled with an ultraviolet-visible detector after the extraction process. In this way, the type of filter and sample dilution order were evaluated in addition to the method's figures of merit. Hence, purification of the biological samples via ultra-centrifugal filters results in a successful electromembrane extraction procedure in the presence of high applied voltages (≥300 V). It brings notable augmentation in the extraction recoveries. As a result, a reduction in the amount of electrical current of the extraction system (17.0-30.0 µA for plasma and 23.0-33.0 µA for urine) and acceptable repeatability (4.6-12.9%) were observed. In the water, linearity was attained between 25.0 and 1000.0 ng/mL; besides, limits of quantification were in the range of 10.0-25.0 ng/mL, and limits of detection were between 3.0 and 7.5 ng/mL.

show abstract

“…As discussed above, the extraction current is important in EME, and should be kept as low as possible in order to avoid excessive electrolysis. A recent paper investigated extraction current in details [60] . In this paper, minimum recovery and repeatability occurred at the highest investigated magnitude of electrical current.…”

Section: Recent Trendsmentioning

confidence: 99%

Electromembrane extraction–Recent trends and where to go

Pedersen‐Bjergaard

Huang

Gjelstad

2017

Journal of Pharmaceutical Analysis

View full text Add to dashboard Cite

Electromembrane extraction (EME) is an analytical microextraction technique, where charged analytes (such as drug substances) are extracted from an aqueous sample (such as a biological fluid), through a supported liquid membrane (SLM) comprising a water immiscible organic solvent, and into an aqueous acceptor solution. The driving force for the extraction is an electrical potential (dc) applied across the SLM. In this paper, EME is reviewed. First, the principle for EME is explained with focus on extraction of cationic and anionic analytes, and typical performance data are presented. Second, papers published in 2016 are reviewed and discussed with focus on (a) new SLMs, (b) new support materials for the SLM, (c) new sample additives improving extraction, (d) new technical configurations, (e) improved theoretical understanding, and (f) pharmaceutical new applications. Finally, important future research objectives and directions are defined for further development of EME, with the aim of establishing EME in the toolbox of future analytical laboratories.

show abstract

Study on electrical current variations in electromembrane extraction process: Relation between extraction recovery and magnitude of electrical current

Cited by 34 publications

References 35 publications

Investigation of the continuous flow of the sample solution on the performance of electromembrane extraction: Comparison with conventional procedure

Investigation of the continuous flow of the sample solution on the performance of electromembrane extraction: Comparison with conventional procedure

An investigation on the effect of filtration and dilution of biological samples on electromembrane extraction efficiency: Determination of basic drugs in plasma and urine samples

Electromembrane extraction–Recent trends and where to go

Contact Info

Product

Resources

About