In this work, a typical vehicle engine is modeled within PTC-Creo software, and its thermal, mechanical, and thermo-mechanical performance are evaluated. This is followed by the vibrational, fatigue, and buckling analysis of the assembly of components, which are the predominant failure causes. The results show that the least temperature gradient occurs in the center of the pin, which connects the piston to the connecting rod, the maximum displacement is seen just below the piston head, and the thermo-mechanical failure is caused mostly (about 85%) by the mechanical load rather than the thermal one. Also, in fatigue analysis, the minimum and maximum values for the safety factor are 0.63 and 5, respectively. The results can prevent the reoccurrence of similar failures and help the enhancement of the components’ design and manufacturing process.