GH4169 alloy is a precipitation-strengthened nickel-chromium-iron-based superalloy, widely known for its challenging machinability in thread rolling processes. The optimization of bolt thread rolling process parameters holds significant research importance, particularly for ensuring batch stability in the production of high-end aerospace fasteners. GH4169 bolts are prone to metallographic folding in the crest and root areas after thread rolling, necessitating the urgent need to optimize the thread rolling process parameters. In this study, a finite element simulation model of the GH4169 bolt thread rolling process was established using ABAQUS software. The thread rolling process parameters, including the feed speed of the thread rolling die, feed speed of the thread rolling die, and initial temperature of the workpiece, were optimized through orthogonal simulation. It was found that, while meeting the technical requirements, a smaller thread forming force yielded better results. Range analysis and variance analysis were conducted on the simulation results to determine the influence trend and significance degree of the thread rolling process parameters on the thread forming force. The research findings of this study can effectively guide actual production processes and significantly reduce exploration time in the GH4169 bolt thread rolling process for enterprises.