Study on increased antimicrobial resistance among bacteria isolated from ICUs Zagazig University Hospitals

Abstract

Emergence of antimicrobial resistance among the most important bacterial pathogens is recognized as a major public health threat affecting humans worldwide. Infections caused by resistant bacteria lead to up to twofold higher rates of adverse outcomes compared with similar infections caused by susceptible strains. The negative impacts of antibacterial resistance can be measured at the patient level by increased morbidity and mortality, at the healthcare level by increased resource utilization, higher costs and reduced hospital activity and at the society level by antibiotic treatment guidelines favoring increasingly broad-spectrum empiric therapy. In this study 67 isolates were collected from patients admitted to ICUs of Zagazig University Hospitals, Sharqia, Egypt. The isolates were biochemically identified and their susceptibility to different antimicrobials were tested by Kirby-Bauer standard disk diffusion method. The results showed that the recovered bacteria had high degree of resistance to different antimicrobial classes and 86.25 % were multi drug resistance (MDR). In conclusion high rate of MDR were found in this study that necessitate strict antibiotic dispensing policy to reduce the increased antibiotic resistance.

Prevalence and Antibiotic Resistance Patterns of Multidrug-Resistant (MDR) Bacteria Isolated from Pediatric Intensive Care Units

“…In agreement with our results, an Egyptian study held at Mansoura University pediatric Hospital over the course of a year, Hassan et al 10 reported that vancomycin was the most effective antimicrobial agent against Grampositive infections while amikacin and imipenem were on the top of the antibiotic list of defeating Gramnegative infections. Nazeih et al 19 reported a similar finding in their study where CoNS and S. aureus showed a complete sensitivity to vancomycin, linezolid and tigecycline, yet, same samples showed high resistance (95%-100%) against penicillin, cefazolin, ampicillin, cefotaxime and ampicillin-sulbactam. Similarly, Kahal et al, 2023 16 reported in retrospective cohort study which was done at Damascus Hospital, Syria that the most effective antimicrobial agents against Pseudomonas aeruginosa after colistin were amikacin, imipenem and gentamycin.…”

Detection of Genes of Efflux Pumps (adeB, adeJ and adeG) in Tigecycline Resistant Acinetobacter baumannii Isolated from Benha University Hospital

“…Coincides with our results, Khodier et al 25 in El-Fayoum General Hospital, Egypt, stated that tigecycline resistance was 58.5%. Higher rate was reported by Nazeih et al 26 in ICU at Zagazig University Hospitals, as tigecycline resistance was 73%. Also Deng et al 27 in China reported that tigecycline resistance is 86% (64/74).…”

Antibacterial Effect of Ethanolic Extracts of Dodonaea viscosa L. Jacq. and Mammea americana L. against Staphylococci Isolated from Skin Lesions

“…Antibiotic resistance has increased in recent years due to the inappropriate use of these drugs and is a severe health problem worldwide [ 17 ]. In our study, we observed penicillin and ampicillin insensitivity in isolated strains.…”

“…For these, activated cultures were seeded by extension in MH agar plates; subsequently, discs containing antibiotics (MultiBac I.D.) were placed on the agar plate and incubated at 35°C ±2°C for 16 h to 18 h. Finally, the measurement of inhibition zones (mm) was determined and recorded [ 17 ]. Antibiotics used were ampicillin (AM) 10 μ g, cephalothin (CF) 30 μ g, cefoxitin (CFX) 30 μ g, ciprofloxacin (CPF) 5 μ g, clindamycin (CLM) 30 μ g, dicloxacillin (DC) 1 μ g, erythromycin (E) 15 μ g, gentamicin (GE) 10 μ g, penicillin (P) 10 U, sulfamethoxazole+trimethoprim (SXT) 25 μ g, tetracycline (T) 30 μ g, and vancomycin (V) 30 μ g (Multibac Investigación Diagnóstica I.D.…”