Study on influence of polymer and surfactant on in vitro performance of biodegradable aqueous-core nanocapsules of tenofovirdisoproxil fumarate by response surface methodology

Srikar, Grandhi; Rani, A. Prameela

doi:10.1590/s2175-97902019000118736

Cited by 20 publications

(14 citation statements)

References 38 publications

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“…Amount of the drug entrapped was found to be increased with the higher particle size and EC polymer concentration. In contrast, less particle size would be responsible for low entrapment efficiency, as the small particles could have more surface area to give more prospect for drug escape from the porous nanocage ( Srikar and Rani, 2019 ). BTF being water insoluble drug that enforce its maximum entrapment in nanocarriers.…”

Section: Resultsmentioning

confidence: 99%

Formulation and in vitro evaluation of topical nanosponge-based gel containing butenafine for the treatment of fungal skin infection

Ahmed

Fatima

Anwer

et al. 2021

Saudi Pharmaceutical Journal

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In the current study, four formulae (BNS1-BNS4) of butenafine (BTF) loaded nanosponges (NS) were fabricated by solvent emulsification technology, using different concentration of ethyl cellulose (EC) and polyvinyl alcohol (PVA) as a rate retarding polymer and surfactant, respectively. Prepared NS were characterized for particle size (PS), polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE) and drug loading (DL). Nanocarrier BNS3 was optimized based on the particle characterizations and drug encapsulation. It was further evaluated for physicochemical characterizations; FTIR, DSC, XRD and SEM. Selected NS BNS3 composed of BTF (100 mg), EC (200 mg) and 0.3% of PVA showed, PS (543 ± 0.67 nm), PDI (0.330 ± 0.02), ZP (−33.8 ± 0.89 mV), %EE (71.3 ± 0.34%) and %DL (22.8 ± 0.67%), respectively. Fabricated NS also revealed; polymer-drug compatibility, drug-encapsulation, non-crystalline state of the drug in the spherical NS as per the physicochemical evaluations. Optimized NS (BNS3) with equivalent amount of (1%, w/w or w/v) BTF was incorporated into the (1%, w/w or w/v) carbopol gel. BTF loaded NS based gel was then evaluated for viscosity, spreadability, flux, drug diffusion, antifungal, stability and skin irritation studies. BNS3 based topical gels exhibited a flux rate of 0.18 (mg/cm 2 .h), drug diffusion of 89.90 ± 0.87% in 24 h with Higuchi model following anomalous non-Fickian drug release. The BNS3 based-gel could be effective against pathogenic fungal strains.

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Section: Resultsmentioning

confidence: 99%

Formulation and in vitro evaluation of topical nanosponge-based gel containing butenafine for the treatment of fungal skin infection

Ahmed

Fatima

Anwer

et al. 2021

Saudi Pharmaceutical Journal

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“…In addition, the hydrophobicity of the polymer further influences this trapping. As pointed out by Srikar and Rani, the higher the hydrophobicity of the polymer, the greater the amount of drug trapped and the lower its release from the polymeric system, thus allowing higher EE values.…”

Section: Results and Discussionmentioning

confidence: 97%

“…To determine the EE, the methodologies of Abriata et al . and Srikar and Rani were used with modifications. PN1 was centrifuged in Amicon Ultra Centrifugal Filters with a molecular weight cutoff (MWCO) of 50 kDa (Merck, Darmstadt, Germany) for 20 min at 3600 rpm using an Excelsa II, Mod.…”

Section: Experimental Sectionmentioning

confidence: 99%

New Silver(I) Coordination Compound Loaded into Polymeric Nanoparticles as a Strategy to Improve In Vitro Anti-Helicobacter pylori Activity

Camargo

Silva

et al. 2020

Mol. Pharmaceutics

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Helicobacter pylori inhabits the gastric epithelium and can promote the development of gastric disorders, such as peptic ulcers, acute and chronic gastritis, mucosal lymphoid tissue (MALT), and gastric adenocarcinomas. To use nanotechnology as a tool to increase the antibacterial activity of silver I [Ag(I)] compounds, this study suggests a new strategy for H. pylori infections, which have hitherto been difficult to control. [Ag (PhTSC·HCl)2] (NO3)·H2O (compound 1) was synthesized, characterized, and loaded into polymeric nanoparticles (PN1). PN1 had been developed by nanoprecipitation with poly(ε-caprolactone) polymer and poloxamer 407 surfactant. System characterization assays showed that the PNs had adequate particle sizes and ζ-potentials. Transmission electron microscopy confirmed the formation of polymeric nanoparticles (PNs). Compound 1 had a minimum inhibitory concentration for H. pylori of 3.90 μg/mL, which was potentiated to 0.781 μg/mL after loading. The minimum bactericidal concentration of 7.81 μg/mL was potentiated 5-fold to 1.56 μg/mL in PN. Compound 1 loaded in PN1 displayed better activity for H. pylori biofilm formation and mature biofilm. PN1 reduced the toxicity of compound 1 to MRC-5 cells. Loading compound 1 into PN1 inhibited the mutagenicity of the free compound. In vivo, the system allowed survival of Galleria mellonella larvae at a concentration of 200 μg/mL. This is the first demonstration of the antibacterial activity of a silver complex enclosed in polymeric nanoparticles against H. pylori.

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“…Polymer hydrophobicity can also influence the entrapment efficiency since the encapsulating material is highly hydrophobic; it hampers the encapsulated active molecule’s escape to the aqueous phase, achieving a low efficiency [ 190 ]. The opposite is observed when the entrapped molecule presents higher solubility in the continuous phase than in the dispersed phase, leading to an easy diffusion and good encapsulation efficiency [ 189 ].…”

Section: Factors Influencing Active Molecules Encapsulation Efficiencymentioning

confidence: 99%

Polymers as Encapsulating Agents and Delivery Vehicles of Enzymes

et al. 2021

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Enzymes are versatile biomolecules with broad applications. Since they are biological molecules, they can be easily destabilized when placed in adverse environmental conditions, such as variations in temperature, pH, or ionic strength. In this sense, the use of protective structures, as polymeric capsules, has been an excellent approach to maintain the catalytic stability of enzymes during their application. Thus, in this review, we report the use of polymeric materials as enzyme encapsulation agents, recent technological developments related to this subject, and characterization methodologies and possible applications of the formed bioactive structures. Our search detected that the most explored methods for enzyme encapsulation are ionotropic gelation, spray drying, freeze-drying, nanoprecipitation, and electrospinning. α-chymotrypsin, lysozyme, and β-galactosidase were the most used enzymes in encapsulations, with chitosan and sodium alginate being the main polymers. Furthermore, most studies reported high encapsulation efficiency, enzyme activity maintenance, and stability improvement at pH, temperature, and storage. Therefore, the information presented here shows a direction for the development of encapsulation systems capable of stabilizing different enzymes and obtaining better performance during application.

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Study on influence of polymer and surfactant on in vitro performance of biodegradable aqueous-core nanocapsules of tenofovirdisoproxil fumarate by response surface methodology

Cited by 20 publications

References 38 publications

Formulation and in vitro evaluation of topical nanosponge-based gel containing butenafine for the treatment of fungal skin infection

Formulation and in vitro evaluation of topical nanosponge-based gel containing butenafine for the treatment of fungal skin infection

New Silver(I) Coordination Compound Loaded into Polymeric Nanoparticles as a Strategy to Improve In Vitro Anti-Helicobacter pylori Activity

Polymers as Encapsulating Agents and Delivery Vehicles of Enzymes

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