Micropile groups (MPGs), combined with the advantages of the anti-slip pile and anchor cable, offer an efficient support system that can be used as countermeasures for stabilizing the talus slopes. However, the performance of MPGs in stabilizing the talus slopes is rarely numerically investigated from the continuous-discontinuous viewpoints. To fulfil this knowledge gap, a numerical method coupled with the discrete element method (DEM) with the finite element method (FEM) is proposed first, and validated to be with good accuracy by the centrifuge model tests. A series of cross-scale analysis cases are then adopted to assess the behavior of MPG in the talus slopes, in which the influencing factors are also taken into account. The numerical results indicate that the MPGs reinforcement can significantly improve the stability of the talus slopes, avoiding the potential progressive shallow slip. For the MPGs with different pile spacing, the distribution laws of deformation and internal force are rather similar, but the one whose pile spacing is four times the pile diameter shows better performance. Moreover, the effective anchorage length of MPG is approximately 1/3 of the pile length, and the axial force distribution is influenced by the type of pile bottom constraint and the tangential contact between the micropile and the bedrock. Finally, the “bidirectional anchorage” attributed to the platform and the bedrock can greatly improve the performance of the MPG, which is a non-negligible part of the anti-slip mechanism of the MPG. This study is of great significance for facilitating the design of MPG in stabilizing the talus slopes.