Adaptable technologies capable of reducing contaminants in enclosed spaces are needed. The SARS‐CoV‐2 pandemic has highlighted the vulnerability of current systems forcing the adoption of extreme measures, causing a significant socioeconomic impact. Electrohydrodynamic devices are proposed as a competitive solution that allows obtaining a high degree of viral inactivation with a very low generation of chemical compounds and low power consumption, together with the production of an airflow, which makes its implementation in real environments easy. In this study, airborne positive‐strand RNA viruses are treated with nonthermal atmospheric plasma, achieving >3.4‐logR for HCoV‐229E and Bacteriophage‐MS2 and >2.4‐log SARS‐CoV‐2 at 4W, in a single pass, at O3 and NO2 concentrations ≤0.70 ppm. Electrical, fluid‐dynamic, and chemical characterization provides the design rules.