With the development of network technology and the theory of mass customization for manufacturing, the knowledge production industry was impacted. On the driving of modern knowledge production characteristics and the drawing of the environment demand, a new knowledge production mode -the mass customization for knowledge production, was put forward. Based on the previous studies, the background and the concept model of knowledge production mode based on mass customization are introduced firstly; then, its operation processes are analyzed on spatial and time dimensions separately; finally, some issues are pointed out about the actualize of knowledge production based on mass customization.