Study on Metallo-Beta Lactamase Producing Pseudomonas Species in Clinical Isolates of a Tertiary Care Hospital of Western Odisha

Mukherjee, Shuvankar; Mishra, Suchitra; Tiwari, Shreekant

doi:10.14260/jemds/2020/335

Cited by 1 publication

(1 citation statement)

References 23 publications

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“…As a result, prevention is always preferable to treatment of MBL Pseudomonas infection. 14 IMP, VIM, SPM, GIM and SIM are five separate forms of MBLs whose prevalence is quickly growing. The most common of them are IMP and VIM.…”

Section: Introductionmentioning

confidence: 99%

Study of metallo β lactamase producing pseudomonas aeruginosa and antimicrobial resistance pattern isolated from various clinical specimens at a tertiary care Hospitals Udaipur, Rajasthan

2023

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Background:The most prevalent mechanism of carbapenem resistance is the development of metallo-β lactamase. Metallo-β lactamase is an Ambler class B zincdependent enzyme that can hydrolyze all β lactam antibiotics, including carbapenem. Objective: The purpose of this study was to identify metallo β lactamase producing pseudomonas aeruginosa and antimicrobial resistance pattern isolated from various clinical specimens at a tertiary care hospital in Udaipur, Rajasthan. Methodology: In this study we have analyzed 1000 samples from various clinical samples (Urine, Endrotracheal, Tracheostomy, Pus, Sputum, and C.S.F) and isolate 625 samples of pseudomonas species. Out of 625 samples 506 samples are of Pseudomonas aeruginosa. These 506 samples were further processed for detection of extended spectrum beta lactamase, metallo beta lactamase and AMPc beta lactamase. Result: Out of total 506 samples, we found 151 (29.84%) samples were positive for the extended spectrum beta lactamase (ESBL), 61 (12.05%) samples were positive for metallo beta lactamase (MBL) formation and 125 (24.70%) samples were positive for AMPc beta lactamase. Highest resistance were observed against gefotaxime (55.53%), tigycycline (54.94%) and ceftazidime (51.97%). Conclusion:A routine MBL production test and further research for new antimicrobial drug (which should be less harmful) are needed.

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Section: Introductionmentioning

confidence: 99%

Study of metallo β lactamase producing pseudomonas aeruginosa and antimicrobial resistance pattern isolated from various clinical specimens at a tertiary care Hospitals Udaipur, Rajasthan

2023

ecb

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show abstract

Study on Metallo-Beta Lactamase Producing Pseudomonas Species in Clinical Isolates of a Tertiary Care Hospital of Western Odisha

Cited by 1 publication

References 23 publications

Study of metallo β lactamase producing pseudomonas aeruginosa and antimicrobial resistance pattern isolated from various clinical specimens at a tertiary care Hospitals Udaipur, Rajasthan

Study of metallo β lactamase producing pseudomonas aeruginosa and antimicrobial resistance pattern isolated from various clinical specimens at a tertiary care Hospitals Udaipur, Rajasthan

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