“…This activity of the 1,3,4-thiadiazole ring can be explained by the inductive effect of the sulfur atom and its relatively high aromatic properties. [22,23] These compounds exhibit broad spectrum of biological activities, including antimicrobial, [24,25] antituberculosis, [26] antioxidant, [27] anti-inflammatory, [28] anticonvulsants, [29] antidepressant and anxiolytic, [30] antihypertensive, [31] anticancer [27,32] and antifungal. There are compounds of this class in the active ingredients of some diseases; glaucoma, [33] high altitude sickness, [34] epileptic seizures, [35] idiopathic intracranial hypertension, [36] hemiplegic migraine, [37] cystinuria, [38] obstructive sleep apnea, [39] congenital myasthenic syndromes.…”