Study on Preoperative Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratio (PLR) as a Predictive Factor in Endometrial Cancer

Muangto, Teerapat; Maireang, Karicha; Poomtavorn, Yenrudee; Thaweekul, Yuthadej; Punyashthira, Awassada; Chantawong, Nopwaree; Wisarnsirirak, Pattra; Pattaraarchachai, Junya; Suwannarurk, Komsun

doi:10.31557/apjcp.2022.23.10.3317

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…PLR is the ratio of platelet to lymphocyte. It was not only associated with the outcome of many tumor patients, but also associated with the response of tumor patients to anti-tumor therapy ( 10 , 11 ). Among patients with acute ischemic stroke, higher PLR was possibly associated with poor outcome, reperfusion insufficiency, and infarct size ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Red blood cell count in cerebrospinal fluid was correlated with inflammatory markers on the seventh postoperative day and all associated with the outcome of aneurysmal subarachnoid hemorrhage patients

Min,

Zhao,

et al. 2024

Front. Med.

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BackgroundExploring factors associated with the outcome of patients with aneurysmal subarachnoid hemorrhage (aSAH) has become a hot focus in research. We sought to investigate the associations of inflammatory markers and blood cell count in cerebrospinal fluid with the outcome of aSAH patients.MethodsWe carried a retrospective study including 200 patients with aSAH and surgeries. The associations of neutrophil, lymphocyte, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune inflammation index (SII), system inflammation response index (SIRI), and blood cell count in cerebrospinal fluid on the 1st and 7th postoperative days with the outcome of aSAH patients were investigated by univariate analysis and multivariate logistic regression model.ResultsAccording to the modified Rankin scale (mRS) score, there were 147 patients with good outcome and 53 patients with poor outcome. The neutrophil, NLR, SIRI, and SII levels on the seventh postoperative day in patients with poor outcome were all significantly higher than patients with good outcome, P < 0.05. The multivariate logistic regression model including inflammatory markers and blood cell counts in cerebrospinal fluid on the 1st postoperative day confirmed that red blood cell count in cerebrospinal fluid (≥177 × 109/L; OR: 7.227, 95% CI: 1.160–45.050, P = 0.034) was possibly associated with poor outcome of aSAH patients, surgical duration (≥169 min), Fisher grade (III–IV), hypertension, and infections were also possibly associated with the poor outcome. The model including inflammatory markers and blood cell counts in cerebrospinal fluid on the 7th postoperative day confirmed that red blood cell count in cerebrospinal fluid (≥54 × 109/L; OR: 39.787, 95% CI: 6.799–232.836, P < 0.001) and neutrophil-lymphocyte ratio (≥8.16; OR: 6.362, 95% CI: 1.424–28.428, P = 0.015) were all possibly associated with poor outcome of aSAH patients. The NLR (r = 0.297, P = 0.007) and SIRI (r = 0.325, P = 0.003) levels were all correlated with the count of red blood cells in cerebrospinal fluid.DiscussionHigher neutrophil-lymphocyte ratio and higher red blood cell count in cerebrospinal fluid were all possibly associated with poor outcome of patients with aneurysmal subarachnoid hemorrhage. However, we need a larger sample study.

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Section: Discussionmentioning

confidence: 99%

Red blood cell count in cerebrospinal fluid was correlated with inflammatory markers on the seventh postoperative day and all associated with the outcome of aneurysmal subarachnoid hemorrhage patients

Min,

Zhao,

et al. 2024

Front. Med.

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“…In endometrial cancer patients, PLR ≥ 134.95 was associated with invasion of myometrium ≥50%. [ 19 ] In advanced non-small cell lung cancer patients, higher PLR level was an independent risk factor associated with the first-line chemotherapy efficacy and clinical prognosis. [ 20 ] In addition to tumors, the results of other studies also confirmed the association between PLR level and infection.…”

Section: Discussionmentioning

confidence: 99%

Systemic inflammation response index (SIRI) on the 3rd postoperative day are associated with severe pneumonia in cerebral hemorrhage patients: A single-center retrospective study

Zhao,

Wang,

Ren

et al. 2023

Medicine

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Inflammatory response was involved in the progression of cerebral hemorrhage. We sought to explore the associations of easily obtained inflammatory indicators including blood cell counts and the ratios of different blood cells counts with pneumonia and severe pneumonia in cerebral hemorrhage patients. We carried 1 retrospective study including 200 patients with cerebral hemorrhage and surgeries. The associations of neutrophils, lymphocytes, monocytes, platelets, systemic immune inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) with pneumonia and severe pneumonia in cerebral hemorrhage patients were estimated by univariate analysis and multivariate logistic regression model. Among the 200 patients included, there were a total of 163 (81.5%) had pneumonia after surgeries. Among 163 cerebral hemorrhage patients with pneumonia, 60 (36.8%) cases were evaluated as severe pneumonia. The level of SIRI on the 1st postoperative day in patients with severe pneumonia was higher than non-severe pneumonia (10.89 ± 12.10 × 109/L vs 7.14 ± 9.76 × 109/L, P = .003). The level of SIRI on the 3rd postoperative day in patients with severe pneumonia was more significantly higher (7.98 ± 7.46 × 109/L vs 4.10 ± 3.74 × 109/L, P < .001). The results of multivariate analysis showed that SIRI level on the 3rd postoperative day (>6.5 × 109/L) was associated with severe pneumonia in cerebral hemorrhage patients (OR: 4.409, 95% CI: 1.799–10.806, P = .001). SIRI was possibly a superior predictor for severe pneumonia in cerebral hemorrhage patients compared with other inflammatory indicators. On the one hand, we intend to validate the cutoff value of SIRI for predicting severe pneumonia in larger samples and multicenter studies. On the other hand, we also intend to use this index to guide the choice of antibacterial drugs in order to better benefit patients.

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“…Whether PLR can be used to distinguish hyperplasia and cancer from pathologically normal patients remains controversial. However, a large number of studies have confirmed that PLR has a certain predictive value in the progression and prognosis of EC patients, and the increase of PLR is closely related to tumor staging, including muscle invasion, cervical involvement, lymph node involvement, lymphatic vascular space invasion and distant metastasis [5] .Although the available studies do not support the use of PLR in the diagnosis of EC, it appears to be associated with late and distant metastases and is a promising hematologic parameter for evaluating the prognosis of EC.…”

Section: Platelet-to-lymphocyte Ratio (Plr)mentioning

confidence: 99%

Research progress on the relationship between common hematological indicators and endometrial carcinoma

2023

MEDSC

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Endometrial carcinoma (EC) is one of the most common malignant tumors in female reproductive tract, which mainly occurs in perimenopausal and postmenopausal women and has a good prognosis. Due to the increase of life expectancy and the change of living habits, the incidence of cervical cancer has been rising continuously in recent years, and patients are getting younger and younger. In some developed cities in China, the incidence of EC has reached the first place in gynecological malignant tumors. From the point of view of secondary prevention, making early screening strategy is the fundamental way to reduce the incidence of EC. Studies show that the hematological indexes of normal endometrial patients and EC patients are different, which is of great significance for early diagnosis, treatment and improvement of prognosis of EC patients. In order to provide reference for the early diagnosis and treatment of EC, this paper reviews the research status of hematological indexes in the diagnosis and treatment of EC.

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Study on Preoperative Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratio (PLR) as a Predictive Factor in Endometrial Cancer

Cited by 10 publications

References 13 publications

Red blood cell count in cerebrospinal fluid was correlated with inflammatory markers on the seventh postoperative day and all associated with the outcome of aneurysmal subarachnoid hemorrhage patients

Red blood cell count in cerebrospinal fluid was correlated with inflammatory markers on the seventh postoperative day and all associated with the outcome of aneurysmal subarachnoid hemorrhage patients

Systemic inflammation response index (SIRI) on the 3rd postoperative day are associated with severe pneumonia in cerebral hemorrhage patients: A single-center retrospective study

Research progress on the relationship between common hematological indicators and endometrial carcinoma

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