Study on preparation and controlled release in vitro of bergenin-amino polylactic acid polymer

Ren, Yuhui; Shen, Mengyan; Ding, Yabei; Yuan, Mingwei; Jiang, Lin; Liu, Hongli; Yuan, Minglong

doi:10.1016/j.ijbiomac.2020.02.205

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…Its mechanism of action notably implicates the targeting of the antiapoptotic protein Mcl-1 (Myeloid leukemia 1), which is frequently overexpressed in human malignancies [147]. Bergenin presents a limited bioavailability, but there are options to overcome this limitation, notably through the design of semisynthetic derivatives and the use of micro-/nano-delivery systems for a controlled release of the product [133,148,149]. The abundance of bergenin in F. virosa is a major element of the bioactivity of the plant.…”

Section: Derivativesmentioning

confidence: 99%

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Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle

Bailly

2024

Future Pharmacology

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The white berry bush, officially Flueggea virosa (Roxb. ex Willd.) Royle is a medicinal plant distributed throughout tropical areas and traditionally used in Africa, India and China. Root decoctions are used to treat abdominal pain, whereas extracts from the aerial parts serve to treat liver and urinary diseases, inflammatory pathologies and diabetes, among other pathologies. Plant extracts have revealed antiparasitic, antimicrobial, antiepilepsy, antidiabetic, anticancer and analgesic effects. Three main categories of phytochemicals were isolated from F. virosa: polyphenols, with the lead product bergenin; terpenoids, such as the flueggenoids and related podocarpane-type diterpenoids; and many alkaloids derived from securinine and norsecurinine. A remarkable feature of S. virosa is the production of norsecurinine oligomers, including macromolecular tetramers and pentamers, such as fluevirosinines. The most potent anticancer alkaloid in the family is the dimeric indolizidine flueggine B, which was identified as a potential binder to α/β-tubulin dimer, which is a known target for securinine. This review highlights the diversity of phytochemicals identified from S. virosa and the potential therapeutic benefits of dimeric alkaloids. Studies are encouraged to further investigate the therapeutic properties of the lead compounds but also define and finesse the nutritional profile of the edible fruit.

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Section: Derivativesmentioning

confidence: 99%

“…Quantification from a methanolic extract (biomarker). [149] Virosecurinine Viroallosecurinine Leaves (Taiwan) Isolation, structural characterization. Cytotoxic activity against cancer cell lines (EC 50 = 3-8 µM).…”

Section: Compounds Plant Parts Used (Location Of Plant Collection) St...mentioning

confidence: 99%

Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle

Bailly

2024

Future Pharmacology

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“…It was found that in the in vitro biological compatibility and anti-tumor assay, BER-amino PLA was found to have promising biological compatibility and lower cytotoxicity compared to the standard group. It was demonstrated that the chemical immobilization of BER not only provides a great method of administration of the drug, but paves a noble way for the prolonged release of this compound [95].…”

Section: Poly (Lactic Acid) Polymermentioning

confidence: 99%

A Fresh Look on Bergenin: Vision of Its Novel Drug Delivery Systems and Pharmacological Activities

Mehta

Kadian

Dalal

et al. 2022

Future Pharmacology

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Bergenin (BER), a key constituent of Bergenia crassifolia (Saxifragaceae), has gained extensive attention, owing to its array of pharmacological actions, including anti-infective, anti-cancer, anti-diabetic, neuroprotective, hepatoprotective, anti-urolithiatic, anti-hyperuricemic, and anti-bradykinin properties. Despite ever-intensifying support for its therapeutic features, the poor solubility, lower oral bioavailability, shorter half-life, and more intestinal pH degradation (pH 6.8 or above) of BER have puzzled researchers. To circumvent these pharmaceutical challenges, and to improve its therapeutic efficacy, newer approaches have been adopted by research scientists. Thus, a discussion of the existing literature may provide complete information about the advances in delivery strategies for enhancing its utility. This paper summarizes up-to-date works on the design and development of novel delivery carriers of this bioactive compound, such as phospholipid complexes, extended-release core tablets, prodrugs, herbal gels, polyherbal ointments, nanoparticles, and poly (lactic acid) polymers, with the objective of harnessing its full potential. This review also provides a deep insight into its bioactivities, along with mechanisms. Additionally, the physicochemical attributes, chemistry, and pharmacokinetics of BER are discussed herein. Hence, the comprehensive information documented in this review may introduce new avenues for research advancements of BER.

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Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages

Nnamani,

Nwagwu,

Diovu

et al. 2024

European Journal of Pharmaceutics and Biopharmaceutics

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Study on preparation and controlled release in vitro of bergenin-amino polylactic acid polymer

Cited by 6 publications

References 36 publications

Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle

Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle

A Fresh Look on Bergenin: Vision of Its Novel Drug Delivery Systems and Pharmacological Activities

Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages

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