Esterified macromonomers (P1) were obtained from methacrylic acid(MAA), maleic anhydride(MAn) and methoxy polyethylene glycol monomethyl ether (MPEG). A low sensitive polycarboxylate superplasticizer (P-DMG) was prepared by copolymerization of Esterified macromonomers (P1) with acrylic acid (AA), hydroxyethyl acrylate (HEA), acryloyloxyethyl trimethyl ammonium chloride (DAC) and 4-hydroxybutyl vinyl polyoxyethylene ether (VPEG). Compared with the conventional polycarboxylate superplasticizer, P-DMG can reduce the sensitivity to concrete dosage, water consumption, temperature and raw materials, and has good workability. It can be widely used in various concrete projects.