Study on preparation of pregna‐4‐en‐17<i>α</i>,21‐diol‐3,20‐dione from androst‐4‐en‐3,17‐dione

Huy, Luu Duc; Tu, Duong N.; Diep, Nguyen T.; Khanh, Ho V.; Kazantsev, A. V.; Savinova, T. S.

doi:10.1002/vjch.202100052

Vietnam Journal of Chemistry

2021

DOI: 10.1002/vjch.202100052

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Study on preparation of pregna‐4‐en‐17α,21‐diol‐3,20‐dione from androst‐4‐en‐3,17‐dione

Luu Duc Huy,

Duong N. Tu,

Nguyen T. Diep

et al.

Abstract: An efficient procedure was proposed for the preparation of pregna‐4‐en‐17α,21‐diol‐3,20‐dioneby using nitrile method to result in high yield up to 56.0‐57.0 % from androst‐4‐en‐3,20‐dione, a key intermediate for producing corticoids.

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2025

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Synthesis of Pregna-1,4,16-triene-3,20-dione from a Mixture of Soybean Phytosterols using a Combination of Chemical and Microbiological Methods

Huy,

Savinova,

Kazantsev

et al. 2025

COC

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In this paper, we present an efficient procedure for the transformation of a soybean phytosterol mixture into pregna-1,4,16-triene-3,20-dione, which is a key intermediate for the synthesis of valuable corticoids. The possibility of using two alternative methods for 1(2)-dehydrogenation of pregna-4,16-diene-3,20-dione - chemical and microbiological - was shown. Microbiological 3-keto-4-ene steroid 1(2)-dehydrogenation was carried out using actinobacterial cells of Nocardioides simplex VKM Ac-2033D. The structures of the synthesized compounds were confirmed by the IR, MS, and 1H-NMR methods.

show abstract

Synthesis of Pregna-1,4,16-triene-3,20-dione from a Mixture of Soybean Phytosterols using a Combination of Chemical and Microbiological Methods

Huy,

Savinova,

Kazantsev

et al. 2025

COC

View full text Add to dashboard Cite

show abstract

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Study on preparation of pregna‐4‐en‐17α,21‐diol‐3,20‐dione from androst‐4‐en‐3,17‐dione

Abstract: An efficient procedure was proposed for the preparation of pregna‐4‐en‐17α,21‐diol‐3,20‐dioneby using nitrile method to result in high yield up to 56.0‐57.0 % from androst‐4‐en‐3,20‐dione, a key intermediate for producing corticoids.

Cited by 1 publication

References 15 publications

Synthesis of Pregna-1,4,16-triene-3,20-dione from a Mixture of Soybean Phytosterols using a Combination of Chemical and Microbiological Methods

Synthesis of Pregna-1,4,16-triene-3,20-dione from a Mixture of Soybean Phytosterols using a Combination of Chemical and Microbiological Methods

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