Study on reversal of ABCB1 mediated multidrug resistance in Colon cancer by acetogenins: An in-silico approach

A Review on Annona muricata and Its Anticancer Activity

“…In vivo SW620 (human colorectal cancer) and in vitro RKO (poorly differentiated colon carcinoma) cell lines revealed that treatment with AA005 showed down-regulation in Bcl 2 and Mcl-1 [ 55 ]. In silico research on acetogenins reverse ABCB1-mediated multidrug resistance in colon cancer: Annohexocin, Annomuricin, Annomuricin B, Annomuricin E, Annonacin A, Annonacin, Annonacin-10-one, Annonacinone, Annopentocin, Annopentocin B, Annopentocin C, Cis-corossolone, Corossolone SL, Epomuricenin A, Epomuricenin B, Gigantetrocin A, Gigantetronenin, Goniothalamicin, Muricapentocin, Muricatocin A, Muricatocin B, Muricoreacin, Solamin revealed that Annonacin, Annohexocin and Annomuricin showed the highest docking scores [ 56 ].…”

Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance

“…It is known that multidrug resistance (MDR) in cancer cells is primarily because of overexpression of ATP-binding cassette transporters such as ABCB1 ( Priya et al., 2022 ). To verify the correlation between the frequency of heterotypic CIC structures and drug resistance in vivo, reflecting the tumor microenvironment, and in a three-dimensional human cancer organoid similar to an actual tumor, an anticancer drug resistance experimental model was established using the ABCB1 gene.…”

Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

“…Thus, we conducted blind docking studies considering the entire MSDs of the ABCA7 homology model using AutoDock [129] . The MSDs as docking space were particularly chosen because they cover the suggested/outlined binding sites in other ABCA transporters [96] , [97] , [98] , which is generally supported by the structural information of other ABC transporters subfamilies [100] , [101] , [102] , [103] , [104] , [105] , [106] , [107] , [108] , [109] , [110] , [111] , [112] , [113] , [114] . Fig.…”

“…The present study aimed for the development of an ABCA7 homology model and subsequent blind docking analysis of the membrane-spanning domains (MDDs) with the pan-ABC transporter inhibitors 6 – 28 , as the multitarget biding site that is supposed to be shared amongst several subfamily members of ABC transporters was postulated to be located in the proximity of the MSDs [4] . This postulation is supported by cryo-EM (ABCB1 [102] , ABCB2 [103] , ABCB4 [104] , ABCC8 [105] , and ABCG2 [106] ) and homology model data (ABCB1 [107] , ABCB2 [108] , ABCB5 [109] , ABCC1 [110] , ABCC4 [111] , ABCC5 [100] , ABCC6 [112] , ABCC7 [113] , ABCC11 [114] , and ABCG2 [101] ) of other ABC transporters which had their primary substrate/inhibitor binding sites within the transmembrane regions.…”