Study on some predelivery immunoparameters in pregnant women in Al-Ramadi city

Abstract

Serum Protein plays major role to maintain balance of blood, so total protein may be elevated or decreased due to some pathological & physiological changes in human body during pregnancy period. On the other hand the serological diagnosis of antibodies level during pregnancy is usually based on the detection of IgG and IgM antibodies as markers for diagnosis. The aim of this study was to investigate some immunoparameters including IgM, IgG, and assay of TSP, TSA & TSG in pregnant women attending Maternity & Child Hospital in Ramadi City, West of Iraq. Sera of 50 pregnant women were collected & quantitative assays by Single Radial Immunodiffusion test (Mancini test) for detection of (IgM & IgG) concentration & spectrophotometric method for Total serum protein, Total serum Albumin & Total serum Globulin reader were achieved against these serum samples. Serum immunoglobulin (IgM & IgG) were measured in 50 pregnant women. (22) with natural delivery & (28) Cesarean delivery pregnant women. The mean IgG level was increased in pregnant women aged under 25 years, while IgM levels were markedly increased at (25-39) years. A total mean titer for IgG & IgM were found to be 1006.2071± 408.12282 & 48.8571±28.81962 respectively. Total serum protein reports separate values for total protein, albumin & Globulin. Values of serum protein reflect high globulin concentration, while albumin concentration in pregnant women recorded significant differences It is mean values for age group (15-24) & (25-39) years are 3.4479 ± .72373 & 3.0044±.33212 respectively. There was significant differences in albumin concentration through age group in pregnant women. Most values of serum routine liver function tests during normal pregnancy remain below the upper normal limits in no pregnant women. When liver disease is suspected & considered pathologic further should prompt evaluation.Furthermore, IgG concentration was predominantly increase in their level during pregnancy in association with transported IgG through placenta to the fetus during late pregnancy period.