Study on TCM Syndrome Identification Modes of Coronary Heart Disease Based on Data Mining

Shi, Qi; Zhao, Huihui; Chen, Jianxin; Ma, Xiang; Yang, Yi; Zheng, Chenglong; Wang, Wei

doi:10.1155/2012/697028

Cited by 30 publications

(21 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using the microarray samples of liver-gallbladder dampness-heat syndrome and liver depression and spleen deficiency syndrome in chronic hepatitis B and liver cirrhosis, Guo et al [73] elucidated the molecular mechanisms of the same TCM syndrome for different diseases and different TCM syndrome for the same disease, which might be related to the G-protein-coupled receptor protein-signaling pathway. Moreover, Shi et al [74] used a complex network and chi-squared automatic interaction detector decision tree to identify the core syndromes of TCM in coronary heart disease (CHD) and establish TCM syndrome identification modes of CHD based on the four diagnostic information and biological parameters.…”

Section: Application Of Network Pharmacology In Chm Researchmentioning

confidence: 99%

Network Pharmacology: A New Approach for Chinese Herbal Medicine Research

Zhang

Chen

et al. 2013

Evidence-Based Complementary and Alternative Medicine

200

185

View full text Add to dashboard Cite

The dominant paradigm of “one gene, one target, one disease” has influenced many aspects of drug discovery strategy. However, in recent years, it has been appreciated that many effective drugs act on multiple targets rather than a single one. As an integrated multidisciplinary concept, network pharmacology, which is based on system biology and polypharmacology, affords a novel network mode of “multiple targets, multiple effects, complex diseases” and replaces the “magic bullets” by “magic shotguns.” Chinese herbal medicine (CHM) has been recognized as one of the most important strategies in complementary and alternative medicine. Though CHM has been practiced for a very long time, its effectiveness and beneficial contribution to public health has not been fully recognized. Also, the knowledge on the mechanisms of CHM formulas is scarce. In the present review, the concept and significance of network pharmacology is briefly introduced. The application and potential role of network pharmacology in the CHM fields is also discussed, such as data collection, target prediction, network visualization, multicomponent interaction, and network toxicology. Furthermore, the developing tendency of network pharmacology is also summarized, and its role in CHM research is discussed.

show abstract

Section: Application Of Network Pharmacology In Chm Researchmentioning

confidence: 99%

Network Pharmacology: A New Approach for Chinese Herbal Medicine Research

Zhang

Chen

et al. 2013

Evidence-Based Complementary and Alternative Medicine

200

185

View full text Add to dashboard Cite

show abstract

“…For TCM-related networks, network-based subgroup analysis methods are summarized in Table 3. Several subgroup analysis methods have been applied in the analysis of different types of networks in TCM, such as herb-herb [58], symptom-symptom [76], target-target [77], factor-factor [78], and pathway-pathway networks [79]. Thus, valuable herb combinations (basic formulae) [58], meaningful symptom groups [76], or biological entities [80] for differentiating syndromes, and instructive therapy combinations for tumor treatment [78] have been obtained and provide a more comprehensive understanding of TCM principles.…”

Section: Computational Measurements For Network Analysismentioning

confidence: 99%

Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools

Yang

Chen

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The concept of “network target” has ushered in a new era in the field of traditional Chinese medicine (TCM). As a new research approach, network pharmacology is based on the analysis of network models and systems biology. Taking advantage of advancements in systems biology, a high degree of integration data analysis strategy and interpretable visualization provides deeper insights into the underlying mechanisms of TCM theories, including the principles of herb combination, biological foundations of herb or herbal formulae action, and molecular basis of TCM syndromes. In this study, we review several recent developments in TCM network pharmacology research and discuss their potential for bridging the gap between traditional and modern medicine. We briefly summarize the two main functional applications of TCM network models: understanding/uncovering and predicting/discovering. In particular, we focus on how TCM network pharmacology research is conducted and highlight different computational tools, such as network-based and machine learning algorithms, and sources that have been proposed and applied to the different steps involved in the research process. To make network pharmacology research commonplace, some basic network definitions and analysis methods are presented.

show abstract

“…Syndrome research has always been a hot and difficult topic in TCM basic studies [11] because it is conducive to the formation of management. When the diagnosis is confirmed, TCM doctors can choose a therapeutic principle according to it.…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

Integrative Views of the Heart in Chinese and Western Medicine

Liu¹

2017

Integr Med Int

View full text Add to dashboard Cite

There is a general acknowledgement in almost all civilizations that the heart is the most important organ in the human body. Both Chinese medicine and Western traditional medicine have a long history of heart research, but they have developed different points of view based on the basic cognition. Traditional Chinese medicine is good at summarizing the correspondence and relationship between the heart and exterior things. The physiological functions of the heart are governing blood and vessels, controlling the mind, opening into the tongue, manifesting on the face, and so on, while modern Western medicine does well in exploring the anatomical structure, spacial connection, and micromechanical character of the organ. Chinese medicine and Western medicine have established the diagnosis and management system, respectively, from their own angles. Combining the knowledge of Chinese and Western medicine can take the advantages of either of the two, making it deeper and more comprehensive for studying and treating heart diseases.

show abstract

Study on TCM Syndrome Identification Modes of Coronary Heart Disease Based on Data Mining

Cited by 30 publications

References 20 publications

Network Pharmacology: A New Approach for Chinese Herbal Medicine Research

Network Pharmacology: A New Approach for Chinese Herbal Medicine Research

Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools

Integrative Views of the Heart in Chinese and Western Medicine

Contact Info

Product

Resources

About