Study on the Anti-Gout Activity of Chlorogenic Acid: Improvement on Hyperuricemia and Gouty Inflammation

Abstract

Gout is a metabolic disorder associated with hyperuricemia resulting in the deposition of monosodium urate (MSU) crystals in joints and tissues. Lowering serum uric acid (Sur) levels and anti-inflammation are highly essential in treating gout. Chlorogenic acid (CA), as one of the most abundant polyphenols in the Chinese medicines, has been rarely reported to have an anti-gout effect. The model of potassium oxonate (PO)-induced hyperuricemia in mice and MSU crystal-induced inflammation in rats has been established in this study. The potential beneficial effects and mechanisms of CA on hyperuricemia and gouty arthritis were elucidated. The results demonstrated that CA significantly decreased the Sur level by inhibiting the xanthine oxidase (XOD) activity but not increasing the urinary uric acid (Uur) level. In addition, CA also exhibited the effect of suppressing paw swelling. Further investigation indicated that CA improved the symptoms of inflammation induced by MSU crystals by inhibiting the production of proinflammatory cytokines including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). The present study suggests that CA may have a considerable potential for development as an anti-gouty arthritis agent for clinical application.

Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model

“…Among these compounds, chlorogenic acid [13], 3,5-dicaffeoylquinic acid [11], 4,5-dicaffeoylquinic acid methyl ester [10] and 1,5-dicaffeoylquinic acid [12] showed significant inhibition of xanthine oxidase activity and anti-hyperuricemia. Thus, anti-hyperuricemia effects by uricosuric or inhibition of xanthine oxidase way by the G. pensylvanicum extracts can be partially attributed to caffeoylquinic acid derivatives.…”

“…Our previous study demonstrated that G. pensylvanicum extract (GPE) possess many caffeoylquinic acid derivatives and showed potent inhibitory activity against XO in vitro. Meanwhile, caffeoylquinic acid derivatives had been report that they showed potential anti-huperuricemia and anti-gouty arthritis effect [10–13]. In addition, previous pharmacology works on various species of the Gnaphalium genus and its components possess XO inhibitory activity, showed significantly anti-hyperuricemia and anti-gouty arthritis [14–16].…”

Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice

“…Thus, it is clinically desirable to combine a compound with allopurinol therapy to potentiate the effects of allopurinol and to reduce the required high doses of the drug for better treatment safety [6,15]. Some natural products have been effective in hyperuricemic control and gout treatment [16][17][18]. Smilax riparia A. DC, belonging to the genus Smilax in the family Liliaceae, is a botanical widely grown in the southern and central parts of China.…”

Sphingosine Kinase-1 Involves the Inhibitory Action of HIF-1α by Chlorogenic Acid in Hypoxic DU145 Cells

“…It regulates various biological processes and has anti-inflammatory [21], anti-diabetic [22], anti-tumorigenic [23], antioxidative [24], anti-gout [25], and anti-obesity [26] effects. Recently, it has been shown that CA inhibits HIF-1α mRNA expression [27] and angiogenesis through the AKT pathway [28].…”