Study on the association of wall shear stress and vessel structural stress with atherosclerosis: An experimental animal study

Zhang, Teng; Wang, Shuo; Tokgoz, Aziz; Taviani, Valentina; Bird, James; Sadat, Umar; Huang, Yuan; Patterson, Andrew J.; Figg, Nichola; Graves, Martin J.; Gillard, Jonathan H.

doi:10.1016/j.atherosclerosis.2021.01.017

Cited by 12 publications

(8 citation statements)

References 56 publications

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“…Although the impacts of atherosclerosis on location-related hemodynamics (Ahmadpour-B et al 2021 ), arterial tissue degradation (Wang et al 2022 ) and remodeling (Thon et al 2018 ), and their effects on IAs have been investigated using FSI, but to the best of authors’ knowledge, no study has been conducted to investigate the biomechanical aspects of the initiation and formation of ACAs using an FSI simulation and analysis. Several studies conducted using CFD have demonstrated the pathological effects of blood flow on the biomechanics of atherosclerosis (Teng et al 2021 ). On the other hand, some researchers have applied the FSI advantages in their investigations related to the plaque rupture and progression in atherosclerotic arteries (Ebrahimi and Fallah 2022 ), hemodynamic parameters assessment of cerebral aneurysms (Sun et al 2022 ), the blood–artery interaction in abdominal aortic aneurysms (Kang et al 2022 ), and investigation of the influence of postural changes on hemodynamics in the internal carotid artery bifurcation aneurysm (Ballambat et al 2022 ) recently.…”

Section: Introductionmentioning

confidence: 99%

Fluid–structure interaction (FSI) simulation for studying the impact of atherosclerosis on hemodynamics, arterial tissue remodeling, and initiation risk of intracranial aneurysms

Rostam-Alilou

Jarrah

Zolfagharian

et al. 2022

Biomech Model Mechanobiol

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The biomechanical and hemodynamic effects of atherosclerosis on the initiation of intracranial aneurysms (IA) are not yet clearly discovered. Also, studies for the observation of hemodynamic variation due to atherosclerotic stenosis and its impact on arterial remodeling and aneurysm genesis remain a controversial field of vascular engineering. The majority of studies performed are relevant to computational fluid dynamic (CFD) simulations. CFD studies are limited in consideration of blood and arterial tissue interactions. In this work, the interaction of the blood and vessel tissue because of atherosclerotic occlusions is studied by developing a fluid and structure interaction (FSI) analysis for the first time. The FSI presents a semi-realistic simulation environment to observe how the blood and vessels' structural interactions can increase the accuracy of the biomechanical study results. In the first step, many different intracranial vessels are modeled for an investigation of the biomechanical and hemodynamic effects of atherosclerosis in arterial tissue remodeling. Three physiological conditions of an intact artery, the artery with intracranial atherosclerosis (ICAS), and an atherosclerotic aneurysm (ACA) are employed in the models with required assumptions. Finally, the obtained outputs are studied with comparative and statistical analyses according to the intact model in a normal physiological condition. The results show that existing occlusions in the cross-sectional area of the arteries play a determinative role in changing the hemodynamic behavior of the arterial segments. The undesirable variations in blood velocity and pressure throughout the vessels increase the risk of arterial tissue remodeling and aneurysm formation.

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Section: Introductionmentioning

confidence: 99%

Fluid–structure interaction (FSI) simulation for studying the impact of atherosclerosis on hemodynamics, arterial tissue remodeling, and initiation risk of intracranial aneurysms

Rostam-Alilou

Jarrah

Zolfagharian

et al. 2022

Biomech Model Mechanobiol

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“…The induced wall shear stress distribution was validated through PIV measurements, and they suggested the sensitivity of wall shear stress distribution and growth rate was near the aneurysm geometry. Low WSS and high OSI and longer Relative Residence Time (RRT) were associated with the development and progression of atherosclerosis [43].…”

Section: Introductionmentioning

confidence: 99%

Influence of blood pressure and rheology on oscillatory shear index and wall shear stress in the carotid artery

Kumar

Pai

Khader

et al. 2022

J Braz. Soc. Mech. Sci. Eng.

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Atherosclerosis is a localized complication dependent on both the rheology and the arterial response to blood pressure. Fluid–structure interaction (FSI) study can be effectively used to understand the local haemodynamics and study the development and progression of atherosclerosis. Although numerical investigations of atherosclerosis are well documented, research on the influence of blood pressure as a result of the response to physio–social factors like anxiety, mental stress, and exercise is scarce. In this work, a three-dimensional (3D) Fluid–Structure Interaction (FSI) study was carried out for normal and stenosed patient-specific carotid artery models. Haemodynamic parameters such as Wall Shear Stress (WSS) and Oscillatory Shear Index (OSI) are evaluated for normal and hypertension conditions. The Carreau–Yasuda blood viscosity model was used in the FSI simulations, and the results are compared with the Newtonian model. The results reveal that high blood pressure increases the peripheral resistance, thereby reducing the WSS. Higher OSI occurs in the region with high flow recirculation. Variation of WSS due to changes in blood pressure and blood viscosity is important in understanding the haemodynamics of carotid arteries. This study demonstrates the potential of FSI to understand the causes of atherosclerosis due to altered blood pressures.

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“…Irregular vascular geometry, including bifurcation, curvature, and branching, can lead to regionally different flow status, which subsequently generates spatial and temporal changes in the shear forces acting on a vessel wall. As a key parameter in cardiovascular hemodynamics, wall shear stress (WSS) (4) expresses the force per unit area exerted by the wall on the blood flow in a direction on the local tangent plane, which is linked to the initiation and progression of many vascular diseases (5)(6)(7). The oscillatory shear index (OSI) is a WSSrelated parameter that describes the WSS directional changes during the cardiac cycle.…”

Section: Introductionmentioning

confidence: 99%

Distribution and regional variation of wall shear stress in the curved middle cerebral artery using four-dimensional flow magnetic resonance imaging

Bai¹,

Fu²,

Li³

et al. 2022

Quant Imaging Med Surg

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Background: To investigate the distribution and regional variation of wall shear stress (WSS) in the curved middle cerebral artery (MCA) in healthy individuals using four-dimensional (4D) flow magnetic resonance imaging (MRI).Methods: A total of 44 healthy participants (18 males; mean ages: 27.16±5.69 years) were included in this cross-sectional study. The WSS parameters of mean, minimum, and maximum values, the coefficient of variation of time-averaged WSS (TAWSS CV ), and the maximum values of the oscillatory shear index (OSI) were calculated and compared in the curved proximal (M1) segments. Three cross-sectional planes were selected: the location perpendicular to the beginning of the long axis of the curved M1 segment of the MCA (proximal section), the most curved M1 location (curved M1 section), and the location before the insular (M2) segment bifurcation (distal section). The WSS and OSI parameters of the proximal, curved, and distal sections of the curved M1 segment were compared, including the inner and outer curvatures of the curved M1 section.Results: Of the curved M1 segments, the curved M1 section had significantly lower minimum TAWSS values than the proximal (P=0.031) and distal sections (P=0.002), and the curved M1 section had significantly higher maximum OSI values than the distal section (P=0.001). The TAWSS CV values at the curved M1 section were significantly higher than the proximal (P=0.001) and distal sections (P<0.001). At the curved M1 section, the inner curvature showed a significantly lower minimum TAWSS (P=0.013) and higher maximum OSI values (P=0.002) than the outer curvature.Conclusions: There are distribution variation of WSS and OSI parameters at the curved M1 section of the curved MCA, and the inner curvature of the curved M1 section has the lowest WSS and highest OSI distribution. The local hemodynamic features of the curved MCA may be related to the predilection for ^ ORCID: 0000-0003-0697-4378.

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Study on the association of wall shear stress and vessel structural stress with atherosclerosis: An experimental animal study

Cited by 12 publications

References 56 publications

Fluid–structure interaction (FSI) simulation for studying the impact of atherosclerosis on hemodynamics, arterial tissue remodeling, and initiation risk of intracranial aneurysms

Fluid–structure interaction (FSI) simulation for studying the impact of atherosclerosis on hemodynamics, arterial tissue remodeling, and initiation risk of intracranial aneurysms

Influence of blood pressure and rheology on oscillatory shear index and wall shear stress in the carotid artery

Distribution and regional variation of wall shear stress in the curved middle cerebral artery using four-dimensional flow magnetic resonance imaging

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