Study on the bioactivity changes of hydroxylated sulfonylureas derivatives: A possible metabolism

Ban, Shu Rong; Niu, Cong; Chen, Wen Bin; Yu, Zhi; Wu, Si; Wang, Chen; Xi, Zhen

doi:10.1016/j.cclet.2006.12.012

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…In each case, these inhibitors have equal or better inhibition than any other herbicide groups tested with low micromolar range IC 50 values. In addition, several herbicide derivatives, including 2‐aroxyl‐1,2,4‐triazolo[1,5‐c]pyrimidine and hydroxylated sulfonylureas were also identified based on virtual screening and molecular simulation approaches [93,94]. The detailed structure and inhibition potencies of these compounds against several bacterial AHASs are described below.…”

Section: Inhibitorsmentioning

confidence: 99%

“…The screening identified several inhibitors, each representing a structural class, including 3-phenyl- [1,2,4]triazol-1-yl, substituted triazol-1-yl-pyrimidine derivatives and phenyl-2,3-dihydro-isothiazole derivatives [8,44,92]. In each case, these inhibitors have equal or better inhibition than any other herbicide groups tested with low [93,94]. The detailed structure and inhibition potencies of these compounds against several bacterial AHASs are described below.…”

Section: Other Compoundsmentioning

confidence: 99%

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Bacterial acetohydroxyacid synthase and its inhibitors – a summary of their structure, biological activity and current status

Gedi

Yoon

2012

The FEBS Journal

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Acetohydroxyacid synthase (anabolic AHAS; http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/2/1/6.html) is a thiamin diphosphate‐dependent enzyme that catalyzes the first step in the branched‐chain amino acid (BCAA) biosynthesis pathway. BCAAs are synthesized by plants, algae, fungi and bacteria, although not by animals. Thus, the enzymes of the BCAA biosynthetic pathway are potential targets in the development of herbicides, fungicides and antimicrobial compounds. Plant AHASs are well studied in this regard because specific plant AHAS inhibitors are considered to comprise the most potent herbicides. These inhibitors are also effective against bacterial AHASs, inhibit the growth of several bacterial strains and have little to no toxicity in mammals. This review provides an overview of bacterial AHASs with an update of the current status of AHAS inhibitors.

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Section: Inhibitorsmentioning

confidence: 99%

Section: Other Compoundsmentioning

confidence: 99%

Bacterial acetohydroxyacid synthase and its inhibitors – a summary of their structure, biological activity and current status

Gedi

Yoon

2012

The FEBS Journal

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Synthesis and in vitro Fungicidal Activity of a Series of Novel N‐(Heterocycly)phthalimides

Ban¹,

Chen²,

Xi³

2011

Chin. J. Chem.

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A series of novel phthalimides was prepared and tested for antifungal activity in vitro against seven phytopathogenic fungi: Rhizoctonia solani, Fusarium oxysporum f.sp. cucumerinum Owen., Botrytis cinerea, Fulvia fulva, Sclerotinia sclerotiorum de Bary, Phytophthora capsici, Botryosphaeria berengeriama. The results showed that those compounds holding the structure of 6-methylpyridin-2-yl exhibited good activity against Phytophthora capsici and Botrytis cinerea.

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Study on the bioactivity changes of hydroxylated sulfonylureas derivatives: A possible metabolism

Cited by 2 publications

References 6 publications

Bacterial acetohydroxyacid synthase and its inhibitors – a summary of their structure, biological activity and current status

Bacterial acetohydroxyacid synthase and its inhibitors – a summary of their structure, biological activity and current status

Synthesis and in vitro Fungicidal Activity of a Series of Novel N‐(Heterocycly)phthalimides

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