Study on the Correlation and Clinical Significance of T lymphocyte Subsets, IL-6 and PCT in the Severity of Patients with Sepsis

Li, Qian; Yan, Wei; Li, Sha; Li, Hui

doi:10.12669/pjms.39.1.5711

Cited by 9 publications

(6 citation statements)

References 27 publications

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“…The decrease in T lymphocytes suggests the possibility of immunosuppression. Qian Li et al compared the differences in T lymphocyte subpopulations in different sepsis patients, and the results support the above conclusion [12]. This study incorporated meaningful indicators in univariate analysis into multivariate logistic regression analysis and found that the decrease in CD3+ T cells, the increase in CRP and fever peak are independent risk factors for the occurrence of severe sepsis.…”

Section: Discussionsupporting

confidence: 61%

Correlation between CD3+, CD4+, CD8+ T Lymphocytes and CRP, IL-6, and PCT in Children with Sepsis and their Value in Disease Assessment

2023

J Community Med Public Health

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Objective:To analyze the relationship between CD3+, CD4+, CD8+ T lymphocyte percentages in peripheral blood lymphocytes and CRP, IL-6, and PCT in children with sepsis and its value in evaluating the severity of the disease. Methods: 91 children diagnosed with sepsis who were hospitalized at the First Affiliated Hospital of Xinxiang Medical College from December 2019 to April 2021 were retrospectively included. Among them, 60 were male (65.9%) and 31 were female (34.1%), aged 3 (1.00, 7.00) years old. Group according to severity of illness. Data were collected within 24 hours of admission. Spearman correlation was used to analyze the relationship between the percentages of CD3+T, CD4+T, CD8+T lymphocytes and CRP, IL-6, and PCT. The non-parametric rank sum test was used to compare differences between mild and severe groups. Logistic regression was used to analyze the relationship between CD3+T, CD4+T, CD8+T lymphocytes and sepsis. Build predictive models to evaluate conditions. Use the Receiver-Operating Curve (ROC) to evaluate the model effect. Results: CD3+T lymphocytes were negatively correlated with PCT, P=<0.001; P=<0.001;). CD8+T lymphocytes were negatively correlated with PCT and CRP (r=-0.215, P=0.041, r=-0.310, P=0.003). There was a negative correlation between the percentage of CD4+T lymphocytes and PCT (r=-0.224, P=0.033). The fever peak, CT3+T (%), CD8+T (%), PCT, CRP, and IL-6 in the mild group were lower than those in the severe group. CD3+T lymphocyte percentage, CRP, and fever peak are risk factors for severe sepsis. Conclusion: The increases in CRP, IL-6, and PCT are negatively correlated with CD3+T, CD8+T, and CD4+T lymphocytes. CD3+T lymphocytes combined with CRP and fever peak can improve the performance of predicting the occurrence of severe sepsis.

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Section: Discussionsupporting

confidence: 61%

Correlation between CD3+, CD4+, CD8+ T Lymphocytes and CRP, IL-6, and PCT in Children with Sepsis and their Value in Disease Assessment

2023

J Community Med Public Health

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“…As reported, the absolute counts of CD3+ T cells, CD4+ T cells, CD8+ T cells, B cells, and natural killer cells were associated with clinical prognosis in septic patients. Especially, the CD8+ T cell count was predictive of sepsis progression, and lymphopenia and CD8+ T cell depletion was associated with the clinical outcomes of sepsis [30][31][32]. Here, we did not analyze the association between each lymphocyte subset and clinical outcomes.…”

Section: Discussionmentioning

confidence: 97%

Establishment and assessment of mortality risk prediction model in patients with sepsis based on early-stage peripheral lymphocyte subsets

Li,

Qu,

et al. 2024

Aging

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This study is aimed to explore the value of lymphocyte subsets in evaluating the severity and prognosis of sepsis. The counts of lymphocytes, CD3+ T cells, CD4+ T cells, CD8+ T cells, CD19+ B cells, and NK cells significantly decreased between day 1 and day 3 in both the survivor and the non-survivor groups. The peripheral lymphocyte subsets (PLS) at day 1 were not significantly different between the survivor and the nonsurvivor groups. However, at day 3, the counts of lymphocytes, CD3+ T cells, CD4+ T cells, and NK cells were remarkably lower in the non-survivor group. No significant differences in CD8+ T cells, or CD19+ B cells were observed. The PLS index was independently and significantly associated with the 28-day mortality risk in septic patients (OR: 3.08, 95% CI: 1.18-9.67). Based on these clinical parameters and the PLS index, we developed a nomograph for evaluating the individual mortality risk in sepsis. The area under the curve of prediction with the PLS index was significantly higher than that from the model with only clinical parameters (0.912 vs. 0.817). Our study suggests that the decline of PLS occurred in the early stage of sepsis. The new novel PLS index can be an independent predictor of 28-day mortality in septic patients. The prediction model based on clinical parameters and the PLS index has relatively high predicting ability.

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“…T-cell dysfunction is a sign of sepsis immune dysfunction (42). Li et al suggested that for patients with sepsis, severe sepsis, and septic shock, the levels of CD3+, CD4 +, and CD4+/CD8+ decreased significantly with the aggravation of the disease (43). The better the patient recovers after treatment, the higher the levels of CD3+, CD4+, and CD4+/CD8+, and the two are positively correlated.…”

Section: Discussionmentioning

confidence: 99%

Effect of Stratified Dose of Norepinephrine on Cellular Immune Response in Patients With Septic Shock and the Construction of a Prognostic Risk Model

Wang,

Tang,

et al. 2024

Shock

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Objective To explore the effect of a stratified dose of norepinephrine (NE) on cellular immune response in patients with septic shock, and to construct a prognostic model of septic shock. Methods A total of 160 patients with septic shock (B group) and 58 patients with sepsis (A group) were given standard cluster therapy. Patients with septic shock were divided into four groups (B1-B4 groups: 0.01-0.2, 0.2-0.5, 0.5-1.0, and > 1 μg/kg/min) according to the quartile method of the early (72 h) time-weighted average dose of NE and clinical application. The cellular immune indexes at 24 h (T0) and 4-7 days (T1) after admission were collected. The difference method was used to explore the effect of NE stratified dose on cellular immune effect in patients with septic shock. A multivariate COX proportional risk regression model was used to analyze the independent prognostic risk factors, and a prognostic risk model was constructed. Results The differences of ΔIL-1β, ΔIL-6, ΔIL-10, absolute value difference of T lymphocyte (ΔCD3+/CD45 + #) and Th helper T cell (ΔCD3+ CD4+/CD45 + #), CD64 infection index difference, ΔmHLA-DR, regulatory T lymphocyte ratio difference (ΔTregs%) between group A, B1, B2, B3 and B4 were statistically significant (p < 0.05). There was a nonlinear relation between the stratified dose of NE and ΔIL-6, ΔIL-10, ΔCD3+/CD45 + #, ΔmHLA-DR%. The threshold periods of NE-induced pro-inflammatory and anti-inflammatory immune changes were 0.3-0.5 μg/kg/min. Multivariate COX model regression analysis showed that age, nutritional patterns, weighted average dose of norepinephrine, IL-6, absolute value of T lymphocytes, and mHLA-DR were independent risk factors affecting the prognosis of patients with septic shock (p < 0.05). The prognostic risk model was constructed (AUC value = 0.813, 95%CI: 0.752-0.901). Conclusion NE has a certain inhibitory effect on cellular immune function in patients with septic shock. A prognostic risk model was constructed with stronger prediction efficiency for the prognosis of patients with septic shock.

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Study on the Correlation and Clinical Significance of T lymphocyte Subsets, IL-6 and PCT in the Severity of Patients with Sepsis

Cited by 9 publications

References 27 publications

Correlation between CD3+, CD4+, CD8+ T Lymphocytes and CRP, IL-6, and PCT in Children with Sepsis and their Value in Disease Assessment

Correlation between CD3+, CD4+, CD8+ T Lymphocytes and CRP, IL-6, and PCT in Children with Sepsis and their Value in Disease Assessment

Establishment and assessment of mortality risk prediction model in patients with sepsis based on early-stage peripheral lymphocyte subsets

Effect of Stratified Dose of Norepinephrine on Cellular Immune Response in Patients With Septic Shock and the Construction of a Prognostic Risk Model

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