Study on the correlation between adipocyte fatty‐acid binding protein, glucolipid metabolism, and pre‐eclampsia

Lin, Yingyan; Xu, Cai-lin; Lin, Kui-Sheng; Gu, Hanming; Chen, Lei; Wang, Ying; Weng, Bao-Chuan; Huang, Haiqing; Li, Yaping; Zou, Yuliang; Li, Zishun

doi:10.1111/jog.13557

Cited by 11 publications

(7 citation statements)

References 15 publications

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“…Our previous study, performed on early postpartum women with GDM or with excessive gestational weight gain, revealed that the maternal serum FABP4 concentrations correlated positively with the lipid profile (i.e., total cholesterol, HDL, and LDL levels), and they also correlated negatively with HgbA1c concentrations in healthy puerperal mothers [18]. Yan and Wang [31], as well as Lin et al [43], noticed that the mean maternal serum FABP4 concentrations correlated negatively with HDL and positively with triglycerides and total cholesterol in patients with pre-eclampsia. Fuseya et al [44] and Ishimura et al [45] showed similar correlations in healthy patients of both sexes.…”

Section: Discussionmentioning

confidence: 99%

FABP4 in Gestational Diabetes—Association between Mothers and Offspring

Patro-Małysza

Trojnar

Kimber-Trojnar

et al. 2019

JCM

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Fetuses exposed to gestational diabetes mellitus (GDM) have a higher risk of abnormal glucose homeostasis in later life. The molecular mechanisms of this phenomenon are still not fully understood. Fatty acid binding protein 4 (FABP4) appears to be one of the most probable candidates involved in the pathophysiology of GDM. The main aim of the study was to investigate whether umbilical cord serum FABP4 concentrations are altered in term neonates born to GDM mothers. Two groups of subjects were selected—28 healthy controls and 26 patients with GDM. FABP4, leptin, and ghrelin concentrations in the umbilical cord serum, maternal serum, and maternal urine were determined via an enzyme-linked immunosorbent assay. The umbilical cord serum FABP4 levels were higher in the GDM offspring and were directly associated with the maternal serum FABP4 and leptin levels, as well as the prepregnancy body mass index (BMI) and the BMI at and after delivery; however, they correlated negatively with birth weight and lipid parameters. In the multiple linear regression models, the umbilical cord serum FABP4 concentrations depended positively on the maternal serum FABP4 and negatively on the umbilical cord serum ghrelin levels and the high-density lipoprotein cholesterol. There are many maternal variables that can affect the level of FABP4 in the umbilical cord serum, thus, their evaluation requires further investigation.

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Section: Discussionmentioning

confidence: 99%

FABP4 in Gestational Diabetes—Association between Mothers and Offspring

Patro-Małysza

Trojnar

Kimber-Trojnar

et al. 2019

JCM

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“…Impairment of lipid metabolism in women with obesity is found by many researchers 1,6,[9][10][11][12][13] . Increasing TC, LDL cholesterol, and TG with a decrease in HDL cholesterol are considered to be risk factors of perinatal complications, in particular placental dysfunction 2,[14][15][16][17][18][19] .…”

Section: Resultsmentioning

confidence: 98%

Examination of the Lipid Profile in Pregnant Obese Women, Considering the Allele Status of the Genes of Angiotensin-Converting Enzyme (Ace I / D) and Plasminogen-1 (Pa-1 4g / 5g) Activator-Inhibitor

BULYK¹,

Rynzhuk²,

GRESKO³

et al. 2018

Arch Balk Med Union

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“…Several studies have noted positive correlations between FABP4 and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triacylglycerol, or adiponectin and TNF-α (26,27) . In addition, Lin et al (28) displayed that serum A-FABP was positively correlated with triglycerides, total cholesterol, and HOMA-IR. In the same line, clinical studies have shown that elevation of serum FABP4 is associated with obesity, insulin resistance, hypertension, and atherosclerosis (29,30) .…”

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Level of Adipocyte Fatty Acid Binding Protein in Patients with Psoriasis Vulgaris before and after Treatment with Acitretin

Darwish¹,

Dakrory²,

Hendawy

2022

The Egyptian Journal of Hospital Medicine

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Background: Psoriasis is a common immune mediated and chronic inflammatory skin disorder portrayed as hyperproliferation and maturation impairment of keratinocytes, increased immune cells infiltration and blood vessel formation, and accumulation in proinflammatory cytokines. Psoriasis is now considered a systemic disease where it is associated with psychological, metabolic, arthritic, and cardiovascular comorbidities. Lifespan is reduced as a consequence.Objective: The aim of this study was to evaluate serum level of adipocyte fatty acid-binding protein (FABP4) in patients with psoriasis vulgaris and to compare it with its level in healthy control. Patients and methods: Seventy-four were included in this study. They were chosen from the Out-patient Clinic of Dermatology, Andrology & STDs Department, Mansoura University Hospitals. A case study group of 37 patients with psoriasis vulgaris and 37 of healthy people age-and sex-matched were used as a control group. Results: ROC curve for detection of FABP4 before acitretin validity in differentiating studied cases illustrated excellent area under curve of 0.728 (p < 0.001)* with the best detected cut off point was 2.7 yielding sensitivity of 75%, specificity of 81.1% and total accuracy of 78.1%. So, the present study demonstrated that; detection of FABP4 level before acitretin therapy could be used as reliable indicator in differentiating studied cases with high sensitivity and specificity. Conclusions: Serum FABP4 levels were significantly increased in patients with psoriasis, indicating that this protein may be a potential marker of psoriasis and an independent predictor for the risk of comorbidities or complications in psoriatic patients. Additionally, it could be used also as a reliable indicator of acitretin therapy.

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Study on the correlation between adipocyte fatty‐acid binding protein, glucolipid metabolism, and pre‐eclampsia

Cited by 11 publications

References 15 publications

FABP4 in Gestational Diabetes—Association between Mothers and Offspring

FABP4 in Gestational Diabetes—Association between Mothers and Offspring

Examination of the Lipid Profile in Pregnant Obese Women, Considering the Allele Status of the Genes of Angiotensin-Converting Enzyme (Ace I / D) and Plasminogen-1 (Pa-1 4g / 5g) Activator-Inhibitor

Assessment of Serum Level of Adipocyte Fatty Acid Binding Protein in Patients with Psoriasis Vulgaris before and after Treatment with Acitretin

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