Study on the correlation of bisphenol A exposure, pro-inflammatory gene expression, and C-reactive protein with potential cardiovascular disease symptoms in young adults

Tsen, Chao-Ming; Liu, Jiahong; DaPeng, Yang; Chao, How‐Ran; Chen, Jyh-Larng; Chou, Wei-Chun; Ho, Yi-Chen; Chuang, Chun‐Yu

doi:10.1007/s11356-021-12805-0

Cited by 14 publications

(13 citation statements)

References 59 publications

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“…Table 1 exhibits the main characteristics of the 20 studies [ 43 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. All included studies were published in the last 15 years (2008–2023).…”

Section: Resultsmentioning

confidence: 99%

“…Studies were carried out in Asian (45.0%), American (30.0%) and European countries (20.0%). The reporting quality was classified as high in 15 studies (75.0%), while five studies (25.0%) had medium reporting quality [ 62 , 66 , 71 , 72 , 73 ]. The risk of bias was classified as very high in two studies [ 58 , 71 ], high in six studies [ 59 , 62 , 65 , 66 , 70 , 72 ], with some concerns in three studies [ 56 , 61 , 68 ], and low in nine studies [ 43 , 57 , 60 , 62 , 63 , 67 , 69 , 73 , 74 ] ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…The reporting quality was classified as high in 15 studies (75.0%), while five studies (25.0%) had medium reporting quality [ 62 , 66 , 71 , 72 , 73 ]. The risk of bias was classified as very high in two studies [ 58 , 71 ], high in six studies [ 59 , 62 , 65 , 66 , 70 , 72 ], with some concerns in three studies [ 56 , 61 , 68 ], and low in nine studies [ 43 , 57 , 60 , 62 , 63 , 67 , 69 , 73 , 74 ] ( Figure 2 ). Taken together, the higher concerns were due to confounding, the measurement of the exposure, and missing data, as shown in Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

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Human Exposure to Bisphenols, Parabens, and Benzophenones, and Its Relationship with the Inflammatory Response: A Systematic Review

Peinado

Iribarne-Durán

Artacho‐Cordón

2023

IJMS

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Bisphenols, parabens (PBs), and benzophenones (BPs) are widely used environmental chemicals that have been linked to several adverse health effects due to their endocrine disrupting properties. However, the cellular pathways through which these chemicals lead to adverse outcomes in humans are still unclear, suggesting some evidence that inflammation might play a key role. Thus, the aim of this study was to summarize the current evidence on the relationship between human exposure to these chemicals and levels of inflammatory biomarkers. A systematic review of peer-reviewed original research studies published up to February 2023 was conducted using the MEDLINE, Web of Science, and Scopus databases. A total of 20 articles met the inclusion/exclusion criteria. Most of the reviewed studies reported significant associations between any of the selected chemicals (mainly bisphenol A) and some pro-inflammatory biomarkers (including C-reactive protein and interleukin 6, among others). Taken together, this systematic review has identified consistent positive associations between human exposure to some chemicals and levels of pro-inflammatory biomarkers, with very few studies exploring the associations between PBs and/or BPs and inflammation. Therefore, a larger number of studies are required to get a better understanding on the mechanisms of action underlying bisphenols, PBs, and BPs and the critical role that inflammation could play.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Human Exposure to Bisphenols, Parabens, and Benzophenones, and Its Relationship with the Inflammatory Response: A Systematic Review

Peinado

Iribarne-Durán

Artacho‐Cordón

2023

IJMS

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“…Their ability to scavenge free radicals is known to play an important role in the prevention of gastric lesions [50]. Bisphenol A on the other hand, is known to induce free radical generation [51] and thus result in a leftward shift in the prooxidant/antioxidant equilibrium [52] and increased inflammation [53].…”

Section: Discussionmentioning

confidence: 99%

Genistein Mitigates the Gastro-Toxic Effects of Bisphenol A in Male Wistar Rats

Ige¹,

Adebayo²,

Adele³

et al. 2022

JBM

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Exposure to Bisphenol A (BPA) worldwide is on the increase. Its toxicities in various tissues expressing estrogen receptors have been reported. However, limited information exists on its effects on the gastric tissue. This study therefore investigated the gastric effects of BPA exposure and the likely ameliorative potential of genistein, a phytoestrogen antioxidant, known to interact with estrogen receptors. Eighty-four male Wistar rats were randomly divided into 6 groups (n = 14) and orally treated for 28 days. Group I-IV received distilled water (0.2 ml), corn oil (3 ml/kg), BPA (50 mg/kg) and genistein (50 mg/kg) respectively. Group V was pre-treated daily with BPA one hour prior to genistein administration while Group VI was pre-treated daily with genistein one hour prior to BPA treatment. Thereafter, blood was collected into heparinized bottles for hematological analysis. Gastric juice was collected for pH and electrolytes determination. Gastric tissue was excised and analyzed for superoxide dismutase (SOD), reduced glutathione (GSH), malondialdehyde, nitric oxide (NO), mucin, parietal and mucous cell counts, and histology. The BPA only treatment group exhibited significant increases (p < 0.05) in white blood cell count, neutrophil-lymphocyte ratio, mucin concentration, NO, and malondialdehyde while gastric juice pH, bicarbonate, SOD, and GSH levels were reduced compared to control. The gastric mucosa also showed pathologies consistent with inflammation. Genistein pre-and post-treatment in BPA exposed rats significantly (p < 0.05) ameliorated these effects of BPA. However, some signs of gastric inflammation were still evident in the mucosal samples. Bisphenol A induces gastro-toxicity by increasing gastric acidity, reducing gastric juice bicarbonate level and disrupting prooxidant/antioxidant balance. Genistein pre-and post-treatment ameliorated these gastro-toxic effects of Bisphenol A via gastroprotective, antioxidant and anti-inflammatory mechanisms.

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“…Recent epidemiological studies have shown associations between BPA levels in adult plasma with coronary and peripheral arterial disease [ 17 , 18 , 19 ]. Maternal BPA exposure alters the transcriptome and structural features of the fetal heart [ 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and Cord Blood Exosomes in a Rat Model

Ermini

Mandalà

Cresti

et al. 2022

Cells

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Dietary exposure to Bisphenol A (BPA), an industrial chemical present in food containers, affects nutrient metabolism in the myocardium of offspring during intrauterine life. Using a murine model, we observed that fetal hearts from mothers exposed to BPA (2.5 μg/kg/day) for 20 days before mating and for all of the gestation had decreased expression of glucose transporter-1 (GLUT1), the principal sugar transporter in the fetal heart, and increased expression of fatty acid cluster of differentiation 36 transporter (CD36), compared to control fetuses from vehicle-treated mothers. We confirmed the suppression of GLUT1 by exposing fetal heart organotypic cultures to BPA (1nM) for 48 h but did not detect changes in CD36 compared to controls. During pregnancy, the placenta continuously releases extracellular vesicles such as exosomes into fetal circulation. These vesicles influence the growth and development of fetal organs. When fetal heart cultures were treated with cord blood-derived exosomes isolated from BPA-fed animals, GLUT1 expression was increased by approximately 40%. Based on our results, we speculate that exosomes from cord blood, in particular placenta-derived nanovesicles, could contribute to the stabilization of the fetal heart metabolism by ameliorating the harmful effects of BPA on GLUT1 expression.

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Study on the correlation of bisphenol A exposure, pro-inflammatory gene expression, and C-reactive protein with potential cardiovascular disease symptoms in young adults

Cited by 14 publications

References 59 publications

Human Exposure to Bisphenols, Parabens, and Benzophenones, and Its Relationship with the Inflammatory Response: A Systematic Review

Human Exposure to Bisphenols, Parabens, and Benzophenones, and Its Relationship with the Inflammatory Response: A Systematic Review

Genistein Mitigates the Gastro-Toxic Effects of Bisphenol A in Male Wistar Rats

Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and Cord Blood Exosomes in a Rat Model

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