The paper discusses the effects of mooring configurations on the dynamic response of a submerged floating offshore wind turbine (SFOWT) for intermediate water depths. A coupled dynamic model of a wind turbine-tower-floating platform-mooring system is established, and the dynamic response of the platform, tensions in mooring lines, and bending moment at the tower base and blade root under four different mooring configurations are checked. A well-stabilized configuration (i.e., four vertical lines and 12 diagonal lines with an inclination angle of 30°) is selected to study the coupled dynamic responses of SFOWT with broken mooring lines, and in order to keep the safety of SFOWT under extreme sea-states, the pretension of the vertical mooring line has to increase from 1800–2780 kN. Results show that the optimized mooring system can provide larger restoring force, and the SFOWT has a smaller movement response under extreme sea-states; when the mooring lines in the upwind wave direction are broken, an increased motion response of the platform will be caused. However, there is no slack in the remaining mooring lines, and the SFOWT still has enough stability.